Reviews October 2025 

• The interplay of tissue mechanics and gene regulatory networks in the evolution of morphogenesis.
  • DiFrisco J, Priya R
  • Seminars in Cell and Developmental Biology
  • doi: 10.1016/j.semcdb.2025.103654
  • PDF

• Mosaic disorders affecting pigmentation - part 1: how to make a clinical diagnosis.
  • Kinsler VA
  • British Journal of Dermatology
  • doi: 10.1093/bjd/ljaf262
  • PDF

• Lung cancer in nonsmoking individuals: A review.
  • Murphy C, Pandya T, Swanton C, Solomon BJ
  • Journal of the American Medical Association (JAMA)
  • doi: 10.1001/jama.2025.17695
  • No Figshare PDF

Cancer

• Penetrant PKCβ mutation in ATLL displays a mixed gain-of-function.
  • Brown SJL, Briggs DC, Costello P, Yaguchi H, Bangham CRM, Parker PJ, McDonald NQ
  • Biochemical Journal
  • doi: 10.1042/BCJ20253384
  • PDF

• The chordoid glioma PRKCA D463H mutation is a kinase inactive, gain-of-function allele that induces early-onset chondrosarcoma in mice.
  • Calleja V, Henry JC, Cobbaut M, Sewell J, Rizzoti K, Houghton F, Boeing S, Anyanwu N, Varsani-Brown S, Snoeks T, Suárez-Bonnet A, Priestnall SL, McDonald NQ, Cameron AJM, Parker PJ
  • Science Signaling
  • doi: 10.1126/scisignal.adr0235
  • No Figshare PDF

• Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma.
  • Cross W, Lyskjær I, Davies C, Bunkum A, Rocha AM, Lesluyes T, Amary F, Tirabosco R, Naceur-Lombardelli C, PEACE consortium, Jamal-Hanjani M, Swanton C, Pillay N, Zaccaria S, Flanagan AM, Van Loo P
  • Genome Biology
  • doi: 10.1186/s13059-025-03812-2
  • PDF

• Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2.
  • Klebba JE, Roy N, Bernard SM, Grabow S, Hoffman MA, Miao H, Tamiya J, Wang J, Berry C, Esparza-Oros A, Lin R, Liu Y, Pariollaud M, Parker H, Mochalkin I, Rana S, Snead AN, Walton EJ, Wyrick TE, Aitchison E, Bedke K, Brannon JC, Chick JM, Hee K, Horning BD, Ismail M, Lamb KN, Lin W, Metzger J, Pastuszka MK, Pollock J, Sigler JJ, Tomaschko M, Tran E, Yue C, Kinsella TM, Molina-Arcas M, Cook BN, Simon GM, Weinstein DS, Downward J, Patricelli MP
  • Science
  • doi: 10.1126/science.adv2684
  • PDF

• Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab.
  • Swanton C, Madison RW, Tambaoan CFB, Meric-Bernstam F, Sweeney CJ, Kurzrock R, Burris III HA, Spigel DR, Tukachinsky H, Hughes J, Malato J, Yoo B, Szado T, Schwab C, Pasquina LW, Gasco A, Schulze K, Friedman CF
  • Molecular Oncology
  • doi: 10.1002/1878-0261.70054
  • PDF

• Preprint: Oncogenic RAS activity is linked to immune priming and adenosine-driven immune evasion in lung adenocarcinoma
  • de Carné Trécesson S, East P, Pillsbury CE, Silva dos Santos M, Cha H, Colliver E, Gilmore T, Rana S, Moore C, Lighterness S, Caswell D, Boumelha J, Tomaschko M, Baer R, Eyles J, Teixeira B, Saeed M, Litchfield K, Molina-Arcas M, Lee S-H, MacRae JI, Hobson P, Swanton C, Downward J
  • doi: 10.1101/2025.11.25.690426

Development and Stem Cells

• A human induced pluripotent stem cell toolbox for studying sex chromosome effects.
  • Meleckyte R, Varsally W, Zohren J, Eriksson J, Incitti T, Starnes L, Pointon A, Hicks R, Powell BE, Turner JMA
  • Stem Cell Reports
  • doi: 10.1016/j.stemcr.2025.102678
  • PDF

• The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube.
  • Zhang I, Boezio GLM, Cornwall-Scoones J, Frith T, Finnie E, Luo J, Jiang M, Howell M, Lovell-Badge R, Sagner A, Briscoe J, Delás MJ
  • Developmental Cell
  • doi: 10.1016/j.devcel.2025.06.029
  • PDF

• Preprint: WNT inhibition primes the transcriptional landscape of mesoderm to initiate a phased ventricular cardiomyocyte specification programme
  • Velecela V, Bassil A, Fawcett E, Smith E, Konstantopoulos D, Salmén F, Bernardo AS, Hoppler S
  • doi: 10.1101/2025.11.11.687613

Genes to Cells

• Collective homeostasis of condensation-prone proteins via their mRNAs.
  • Faraway R, Costello Heaven N, Digby H, Kuret Hodnik K, Rebselj J, Wilkins OG, Chakrabarti AM, Iosub IA, Vadnjal N, Dore R, Knez L, Ameres SL, Plaschka C, Ule J
  • Nature
  • doi: 10.1038/s41586-025-09568-w
  • PDF

• A role for human senataxin in contending with pausing and backtracking during transcript elongation.
  • Han Z, Fu S, Johansen JV, Lopez Martinez D, Lou J, Boissière T, He D, Blears D, Olthof AM, Dirac-Svejstrup AB, Svejstrup JQ
  • Molecular Cell
  • doi: 10.1016/j.molcel.2025.10.019
  • PDF

• Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers.
  • Liu T, Cao L, Mladenov M, Romet-Lemonne G, Way M, Moores CA
  • Nature Structural & Molecular Biology
  • doi: 10.1038/s41594-025-01665-8
  • PDF

• The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking.
  • Pellowe GA, Voisin TB, Karpauskaite L, Maslen SL, Roeselová A, Skehel JM, Roustan C, George R, Nans A, Kjær S, Taylor IA, Balchin D
  • Nature Structural & Molecular Biology
  • doi: 10.1038/s41594-025-01676-5
  • PDF

• Branched actin networks mediate macrophage-dependent host-microbiota homeostasis.
  • Vasconcellos LRC, Huang SCM, Suárez-Bonnet A, Priestnall S, Chakravarty P, Varsani-Brown S, Winder ML, Shah K, Kogata N, Stockinger B, Way M
  • Science
  • doi: 10.1126/science.adr9571
  • No Figshare PDF

• Preprint: PETRA: Prime editing of transcribed regulatory elements to assay expression
  • Armas Reyes M, Herger M, Cubitt L, Findlay GM
  • doi: 10.1101/2025.11.18.689114

• Preprint: Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes
  • Gomez-Gil E, Guerra P, Gu Y, Foo S, Billard B, Balogh G, Peter M, Oliferenko S
  • doi: 10.1101/2025.11.06.686945

• Preprint: Inhibiting epithelial cell extrusion and inflammation synergistically reverses asthmatic airway remodelling
  • Bagley DC, Russell T, Martinez-Nunez RT, Marcotti S, Rosenblatt J
  • doi: 10.1101/2025.11.10.687569

• Preprint: Human airway epithelia clear rhinovirus-infected cells using two waves of cell extrusion
  • Fore F, Bagley D, Martinez-Nunez RT, Aniscenko J, Johnston S, Rosenblatt J
  • doi: 10.1101/2025.11.18.689008

Host and Pathogen

• Trio whole exome sequencing in Chinese childhood-onset lupus reveals novel candidate genes.
  • Ma J, Qin Y, Hong S-M, Ware T, Hou G, Tan J, Xie C, Zhang P, Wu X, Arsov T, Cao L, Andrews TD, Wu P, Shen Q, Ding H, Shen N, Vinuesa CG, He Y
  • Arthritis & Rheumatology
  • doi: 10.1002/art.43243
  • No Figshare PDF

• Cholesterol pathway gene variants and reduced keratinocyte cholesterol support a final common druggable pathway in hyperproliferative inflammatory skin diseases.
  • Riachi M, Bryant D, Ellis J, Hughes C, Polubothu S, Del Valle Torres I, Sauvadet A, Knöpfel N, Muwanga-Nanyonjo N, Barberan-Martin S, Bruzos A, Kelly G, Calvani E, Palma-Duran SA, Silva Dos Santos M, Chaloner C, Khalil Y, Clayton P, Mills P, Bulstrode N, Dand N, Di W-L, Barral P, Simpson MA, Barker J, Lee JC, MacRae J, Kinsler VA
  • Journal of Investigative Dermatology
  • doi: 10.1016/j.jid.2025.02.157
  • PDF

Neuroscience

• TDP-43 loss induces cryptic polyadenylation in ALS/FTD.
  • Bryce-Smith S, Brown A-L, Chien MZYJ, Dattilo D, Mehta PR, Mattedi F, Barattucci S, Mikheenko A, Zanovello M, Pellegrini F, El-Agamy SE, Yome M, Hill SE, Qi YA, Sun K, Ryadnov E, Wan Y, NYGC ALS Consortium, Vargas JNS, Birsa N, Raj T, Humphrey J, Keuss M, Wilkins OG, Ward M, Secrier M, Fratta P
  • Nature Neuroscience
  • doi: 10.1038/s41593-025-02050-w
  • PDF

• Collective homeostasis of condensation-prone proteins via their mRNAs.
  • Faraway R, Costello Heaven N, Digby H, Kuret Hodnik K, Rebselj J, Wilkins OG, Chakrabarti AM, Iosub IA, Vadnjal N, Dore R, Knez L, Ameres SL, Plaschka C, Ule J
  • Nature
  • doi: 10.1038/s41586-025-09568-w
  • PDF

Structural and Chemical Biology

• Results of the protein engineering tournament: An open science benchmark for protein modeling and design.
  • Armer C, Kane H, Cortade DL, Redestig H, Estell DA, Yusuf A, Rollins N, Spinner A, Marks D, Brunette TJ, Kelly PJ, DeBenedictis E
  • Proteins: Structure, Function and Bioinformatics
  • doi: 10.1002/prot.70008
  • PDF

• Progressive chromosome shape changes during cell divisions.
  • Kakui Y, Kusano Y, Clarence T, Lopez M, Fallesen T, Hirota T, Khatri BS, Uhlmann F
  • EMBO Reports
  • doi: 10.1038/s44319-025-00577-4
  • PDF

• The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking.
  • Pellowe GA, Voisin TB, Karpauskaite L, Maslen SL, Roeselová A, Skehel JM, Roustan C, George R, Nans A, Kjær S, Taylor IA, Balchin D
  • Nature Structural & Molecular Biology
  • doi: 10.1038/s41594-025-01676-5
  • PDF

• GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome.
  • Roeselová A, Maslen SL, He JZ, Jurkeviciute G, Pajak A, Skehel JM, Enchev RI, Balchin D
  • Nature Communications
  • doi: 10.1038/s41467-025-64968-w
  • PDF

• Preprint: Anion-controlled structural interconversion of palladium cages enables separations by selective guest capture and release
  • Li Z, Ronson T, McTernan CT
  • doi: 10.26434/chemrxiv-2025-1l3bk

• Preprint: Topological defects drive influenza glycoprotein lattice assembly on spherical membranes
  • Liu ZB, Halldorsson S, Calcraft T, Calder LJ, Rosenthal PB
  • doi: 10.1101/2025.11.06.686978

• Preprint: A structural and regulatory framework for Atg9-containing vesicle formation and their Atg1-dependent remodelling during autophagy initiation
  • Oeo-Santos C, Knüpling E, Davis C, Meng X, Maslen S, Kunzelmann S, D'Antuono R, Olerinyova A, Auchynnikava T, Skehel M, Schreiber A
  • doi: 10.1101/2025.11.06.685569

Clinical

• Hepatitis B virus (HBV) treatment eligibility in the UK: Retrospective longitudinal cohort data to explore the impact of changes in clinical guidelines.
  • Campbell C, Wang T, Stockdale AJ, Todd S, Jaworski J, Glampson B, Papadimitriou D, Mayer E, Salih H, Roadknight G, Little S, Noble T, Várnai KA, Davis C, Heinson AI, George M, Borca F, Roberts T, Ribeyre BB, English L, Zhu L, NIHR HIC Viral Hepatitis and Liver Disease Consortium, Woods K, Davies J, Cooke GS, Nastouli E, Khakoo SI, Gelson W, Elsharkawy AM, Barnes E, Matthews PC
  • Journal of Viral Hepatitis
  • doi: 10.1111/jvh.70098
  • PDF

• Segmental macular hyperpigmentation: new genes, new clinical implications.
  • Kinsler VA, Knöpfel N, Polubothu S
  • British Journal of Dermatology
  • doi: 10.1093/bjd/ljaf254
  • PDF