Reviews October 2025 

• Science, education, leadership, and politics: An interview with Bruce Alberts and Paul Nurse.
  • Alberts B, Nurse P, Schier AF
  • Annual Review of Cell and Developmental Biology
  • doi: 10.1146/annurev-cellbio-101323-034601
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• Determining variant effects with pooled prime editing.
  • Kajba CM, Herger M
  • Nature Reviews Genetics
  • doi: 10.1038/s41576-025-00865-8
  • No Figshare pdf

Cancer

• Subclonal immune evasion in non-small cell lung cancer.
  • Dijkstra KK, Vendramin R, Karagianni D, Witsen M, Gálvez-Cancino F, Hill MS, Foster KA, Barbè V, Angelova M, Hynds RE, Pearce DR, Martínez-Ruiz C, Black JRM, Huebner A, Pich O, Rowan A, Augustine M, Puttick C, Moore DA, Liu LL, Saghafinia S, van de Haar J, Veeriah S, Naceur-Lombardelli C, Toncheva A, Bola SK, Hiley CT, Jamal-Hanjani M, McGranahan N, Litchfield K, Reading JL, Chain B, TRACERx consortium, Quezada SA, Voest EE, Swanton C
  • Cancer Cell
  • doi: 10.1016/j.ccell.2025.06.012
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• HIFα isoform specific activities drive cell-type specificity of VHL-associated oncogenesis.
  • Lima JDCC, Hooker M, Li R, Barros AB, Masson N, Pugh CW, Mole DR, Adam J, Ratcliffe PJ, Kurlekar S
  • Nature Communications
  • doi: 10.1038/s41467-025-64214-3
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• Extrachromosomal DNA-driven oncogene spatial heterogeneity and evolution in glioblastoma.
  • Noorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT-L, Pradella D, Lisi M, Kittel J, Sharma N, Bailey C, Weeden CE, Bell DM, Joo E, Barbè V, Jones MG, Hung KL, Nye EL, Green M, Meader L, Norton EJ, Fabian M, Kanu N, Jamal-Hanjani M, Santarius T, Ventura A, Nicoll JAR, Boche D, Chang HY, Bafna V, Huang W, Mischel PS, Swanton C, Werner B
  • Cancer Discovery
  • doi: 10.1158/2159-8290.CD-24-1555
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• Clone copy number diversity is linked to survival in lung cancer.
  • Pawlik P, Grigoriadis K, Bunkum A, Coggan H, Frankell AM, Martinez-Ruiz C, Karasaki T, Huebner A, Rowan A, Fisher J, Hackshaw A, Swanton C, Zaccaria S, McGranahan N
  • Nature
  • doi: 10.1038/s41586-025-09398-w
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• Preprint: Leveraging death of drug-sensitive cancer cells to promote immune-mediated bystander killing of subclones of drug-resistant tumour cells
  • Tomaschko M, Ng K, Moore C, Pillsbury CE, Rana S, Campbell J, Mukherjee S, Mikolajczak A, Anastasiou P, de Castro A, Alonso de la Vega A, de Carné Trécesson S, Goehring NW, Molina-Arcas M, Downward J
  • doi: 10.1101/2025.10.27.684825

• Preprint: Extensive and differential platinum chemotherapy mutagenesis in children
  • Wenger A, Lee-Six H, Dave M, Layeghifard M, Lawson ARJ, Abascal F, Nicola PA, Treger TD, Ogbonnah T, Parks C, Oliver TRW, Kennedy J, Hodder A, Anderson ND, Silva FLT, Trinh MK, Dowe T, Habarwaa M, Sun JJ, Assia-Zamora S, Cortes-Cerisuelo M, Jassem W, Town
  • doi: 10.1101/2025.10.12.681852

• Preprint: Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma
  • Schlegelmilch K, Hollek V, Hooper S, Giangreco G, Bailey S, Macfarlane S, Carminati A, Bowes A, Strohbuecker S, Fu X, Sahai E
  • doi: 10.1101/2025.10.23.684170

• Preprint: Multicellular calcium waves in cancer-associated fibroblasts regulate neuronal mimicry and anisotropy leading to immune exclusion
  • Giangreco G, Ramsden Z, Rullan A, Hooper S, Novo D, Castro JL, Chakravarty P, Milan M, Mohammadi H, Llop S, Juarez M, Schneider-Luftman D, Oliva M, Alemany L, Angelova M, Olow A, Yu X, Hobson P, Harrington KJ, Sahai E
  • doi: 10.1101/2025.10.23.684281

• Preprint: Cancer-driven neutrophil priming couples systemic epithelial regenerative programs with pre-metastatic niche formation
  • Rabas N, Bridgeman VL, Pospori C, Hennequart M, Rodrigues FS, Farias A, Ferreira RMM, Axarli K, Nduka O, Chakravarty P, Legrave N, Furlani I, Malanchi I
  • doi: 10.1101/2025.10.20.683483

• Preprint: Inhibition of neutrophil degranulation by Nexinhib20 delays the development of radiation-induced pulmonary fibrosis
  • Ruhland S, Nikolatou K, Bridgeman VL, Rizou T, Sahai E, Bordoloi J, Nolan E, Elosegui-Artola A, Malanchi I
  • doi: 10.1101/2025.10.22.684057

• Preprint: Rapid expansion of podoplanin-positive fibroblasts following radiation limits the anti-tumour CD8+ T-cell response to radiotherapy.
  • Wilkins AC, Makris S, Green M, Hooper S, Mikolajczak A, Giangreco G, Allanki S, Nye E, Connick E, Mitter R, Cooper S, Durie E, Pedersen M, Burley A, O'Fee K, O'Leary B, Shewring D, Ramsden Z, Melcher A, Harrington K, Somaiah N, Acton SE, Sahai E
  • doi: 10.1101/2025.10.07.680949

• Preprint: DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells
  • Mantica G, Vedi A, Tuval A, Huerga Encabo H, Hayler D, Krzywon A, Mitchell E, Dunn WG, Biezuner T, Bastos HP, Sham K, Santoro A, Lee J, Williams N, Danin A, Chapal N, Moskovitz Y, Arruda A, Fiorillo E, Orru V, Marongiu M, McKinney E, Cucca F, Collin M, Minden M, Campbell P, Vassiliou G, Fabre MA, Nangalia J, Bonnet D, Shlush L, Laurenti E.
  • doi: 10.1101/2025.10.08.679225

Development and Stem Cells

• Preprint: Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
  • Boezio GLM, Depotter JRL, Frith TJR, Radley A, Strohbuecker S, Cunha AC, Howell M, Briscoe J
  • doi: 10.1101/2025.10.24.684328

Genes to Cells

• Probing the molecular determinants of Ty1 retrotransposon restriction specificity in yeast.
  • Beckwith SL, Cottee MA, Hannon-Hatfield JA, Newman AC, Walker EC, Romero JR, Stoye JP, Taylor IA, Garfinkel DJ
  • PLoS Genetics
  • doi: 10.1371/journal.pgen.1011898
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• Dynamic modelling of cell cycle arrest through integrated single-cell and mathematical modelling approaches.
  • Cortés-Ríos J, Rodriguez-Fernandez M, Sorger PK, Fröhlich F
  • PLoS Computational Biology
  • doi: 10.1371/journal.pcbi.1012890
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• ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair.
  • De Tito S, Almacellas E, Dai Yu D, Millard E, Zhang W, de Heus C, Queval C, Hervás JH, Pellegrino E, Panagi I, Fogde D, Thurston TLM, Klumperman J, Gutierrez M, Tooze SA
  • Developmental Cell
  • doi: 10.1016/j.devcel.2025.05.007
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• Mammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression.
  • Milan M, Runfola V, Patel M, Falbo L, Noberini R, Soriani C, Rodighiero S, Bonaldi T, Costanzo V, Pradeepa MM, Scaffidi P
  • Nucleic Acids Research
  • doi: 10.1093/nar/gkaf916
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• Preprint: Cell cycle oscillations in a polarity network facilitate state switching by morphogenetic cues
  • Ng K, Sebaa H, Hirani N, Chizh A, Messi Z, Bland T, Sugioka K, Goehring NW
  • doi: 10.1101/2025.10.12.681824

Host and Pathogen

• Beneficial and detrimental consequences of AHR activation in intestinal infection.
  • Diaz OE, Zhou L, Barrington C, Lindqvist D, Graelmann F, Wincent E, Stockinger B
  • Life Science Alliance
  • doi: 10.26508/lsa.202503414
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• The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment.
  • Marzook NB, Song O-R, Baumgärtel L, Bernitz N, Mkandawire TT, Watson LC, Nunes V, Warchal S, MacRae JI, Howell M, Sateriale A
  • Cell
  • doi: 10.1016/j.cell.2025.07.001
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• TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function.
  • Shen Q, Wang H, Roco JA, Meng X, Bosticardo M, Hodges M, Battaglia M, Feng Z-P, Talks BJ, Powell J, Shanmugiah VBM, Chu J, Rahman NM, Elsheikh A, Chakravarty P, Grenov A, Emmerich M, Delmonte OM, Freeman AF, Keller MD, Belaid B, Papa I, Lee JC, Cañete PF, Gonzalez-Figueroa P, Zhang Y, Xue H-H, Turajlic S, Notarangelo LD, Haniffa M, Garrett-Sinha LA, Parry HM, Kanellakis NI, Vinuesa CG
  • Nature
  • doi: 10.1038/s41586-025-09421-0
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• Resurgence of zoonotic highly pathogenic avian influenza A(H5N1) virus in Cambodia.
  • Siegers JY, Xie R, Edwards KM, Byrne AMP, Hu S, Wang R, Yann S, Sin S, Tok S, Chea K, Horm S, Rith C, Keo S, Pum L, Duong V, Auerswald H, Phou Y, Kol S, Spiegel A, Harvey R, Tum S, Sorn S, Seng B, Sengdoeurn Y, Chau D, Chin S, Hak M, Ieng V, Patel S, Thielen P, Claes FF, Lewis NS, Ly S, Karlsson EA, Dhanasekaran V
  • New England Journal of Medicine
  • doi: 10.1056/NEJMc2504302
  • No Figshare pdf

• Preprint: SERINC5 is the primary target of retroviral antagonists among human SERINC paralogs and requires a Tri-Cysteine motif for its counteraction by HIV-1 Nef
  • Bertelli C, Rosa A, Vanzo T, Chande A, Serwa R, Tate E, Cherepanov P, Pizzato M
  • doi: 10.1101/2025.10.27.684794

• Preprint: Post-infection pig and ferret antisera show similar antigenic profiles for human influenza A(H1N1pdm09) viruses
  • Harvey R, Cayol T, Paudyal B, Lilley A, Carr C, Hatton C, Briggs E, Daniels RS, Richardson S, Peacock TP, Lewis N, Brown I, McCauley JW, Tchilian E
  • doi: 10.1101/2025.10.30.685573

• Preprint: Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases
  • Lee RJ, Hooper S, Pallett LJ, Diniz M, McKinnon-Snell T, Ramsden Z, Rabas N, Boeing S, Kennedy O, Buttercase C, Aidoo-Micah G, Price G, Macfarlane SC, Bailey S, Davies J, Mathur A, Pistocchi G, Carminati A, Gupta A, Serra P, Davidson B, Pollok J-M, Papayannopoulos V, Malanchi I, Lorigan P, Mala K, Maini MK, Sahai E
  • doi: 10.1101/2025.09.30.679035

• Preprint: Micro-elimination of Hepatitis C virus (HCV) infection in the General Population Cohort in rural Uganda: long-term follow-up to assess feasibility and outcomes of a screening and treatment intervention
  • Mugisha J, Kimono B, Lumley S, O’Hara G, Waddilove E, Wekesa C, Mgomella G, Makanga R, Ndungutse R, Nyirenda M, Davis C, Thomson E, Ocama P, Seeley J, Matthews PC, Newton R
  • doi: 10.1101/2025.10.17.25338164

• Preprint: Autoantibody origins in lupus and in relapse post CAR-T therapy
  • Grenov A, Yoon J, Snell DM, Mikolajczak A, Wang H, Gürel E, Rodriguez-Ronchel A, Yegen G, Lee L, Artim Esen B, Rahman A, Maciocia P, Vinuesa CG
  • doi: 10.1101/2025.10.20.683393

Neuroscience

• Functional specialisation of multisensory temporal integration in the mouse superior colliculus.
  • Bianchini G, Razafindrahaba I, Moglie MJ, Konstantinou G, Cano-Ferrer X, Imbert A, Iacaruso MF
  • Nature Communications
  • doi: 10.1038/s41467-025-64600-x
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• Preprint: The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
  • Mahoney-Sánchez L, Lucas-Clarke H, Penverne A, Evans JR, D'Sa K, Strohbuecker S, López-García P, Cosker K, Soltic D, O'Callaghan B, Griffiths A, Pintchovski SA, Plun-Favreau H, Hallqvist J, Mills K, Gandhi S
  • doi: 10.1101/2025.10.13.682089

Structural and Chemical Biology

• Replisome passage through the cohesin ring
  • Glaser S, Molodtsov MI, Diffley JFX, Uhlmann F
  • Cell
  • doi: 10.1016/j.cell.2025.08.028
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• Conformational dynamics of the bacterial E3 ligase SspH1.
  • Kennedy CR, Esposito D, Huber J, House D, Rittinger K
  • Journal of Biological Chemistry
  • doi: 10.1016/j.jbc.2025.110671
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• Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication
  • Minamino M, Diffley JFX, Uhlmann F
  • Molecular Cell
  • doi: 10.1016/j.molcel.2025.08.026
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• Force-triggered thermodynamically uphill disulfide reduction through sulfur oxidation state control.
  • Mora M, Cohen G, Cranton W, Anton O, Beedle AEM, Stirnemann G, Garcia-Manyes S
  • Journal of the American Chemical Society
  • doi: 10.1021/jacs.5c13084
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• Preprint: Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction
  • Pulschen AA, Booth J, Satanowski A, Soudy C, Caro-Astorga J, Ather O, Patel N, Alidoust A, Aoudjane S, Nematollahi L, DeBenedictis E
  • doi: 10.1101/2025.10.08.681035

• Preprint: Two-dimensional NMR from a Single Pulse: Reconstructing Heteronuclear 2D spectra via off-resonance decoupling and Deep Neural Networks
  • Khandave NP, Kakita VMR, Shukla VK, Haubrich K, Vallurupalli P, Hansen DF
  • doi: 10.1101/2025.10.30.685498

• Preprint: Convergent lead discovery strategies yield covalent and non-covalent inhibitors of human UDP-galactose-4-epimerase
  • Browne W, Pettinger J, Weckwerth T, Purkiss A, Lok SH, Penicaut L, Ogrodowicz R, Morar R, Kunzelmann S, Roustan C, Bineva-Todd G, Pieters S, Zappacosta F, Kjaer S, House D, Mouilleron S, Bush J, Schumann B
  • doi: 10.26434/chemrxiv-2025-96j43

Interdisciplinary

• High-throughput drug screening in a cellular model of KRAS-driven arteriovenous malformations.
  • Michailidis F, Zecchin D, Rabii M, del Valle I, Sauvadet A, Jiang M, Howell M, Bryant D, Polubothu S, Kinsler VA
  • Journal of Investigative Dermatology
  • doi: 10.1016/j.jid.2025.02.151
  • PDF