Reviews August 2025 

• Mechanisms for licensing origins of DNA replication in eukaryotic cells
  • Stillman B, Diffley JFX, Iwasa JH
  • Nature Structural and Molecular Biology
  • doi: 10.1038/s41594-025-01587-5
  • No Figshare PDF

• Novel techniques for the diagnosis of neurological infections.
  • Alam AM, Houlihan CF, Bharucha T
  • Current Opinion in Neurology
  • doi: 10.1097/WCO.0000000000001395
  • No Figshare PDF

• Embracing complexity: Peptides as tuneable scaffolds in the construction of discrete supramolecular systems.
  • Barber BE, Jamieson EMG, White LEM, McTernan CT
  • Angewandte Chemie International Edition
  • doi: 10.1002/anie.202512014
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• Evolution of antiviral host defenses against a backdrop of endogenous retroelements.
  • Kassiotis G, Stoye JP
  • Science
  • doi: 10.1126/science.adx4379
  • No Figshare PDF

• Hepatitis B virus resistance to nucleos(t)ide analogue therapy: WHO consultation on questions, challenges, and a roadmap for the field.
  • Lumley SF, Mokaya J, Maponga TG, Kramvis A, Dusheiko G, Irving W, Delphin M, Said Mohammed K, Downs LO, Waddilove E, Anderson M, Iwuji C, Msomi N, Ocama P, Hamid S, Adda D, Halford R, Kabagambe K, Benschop KSM, Inzaule S, Chan P, Paul MAS, Izumi K, Nisa T, De Dieu Iragena J, Girón-Callejas A, Kpossou AR, Jamiyu G, Emmanuel O, Balkissa M, Keita M, Prabdial-Sing N, Martinez A, Magongo EN, Shao Y, Sued O, Sereno LS, Shafer RW, Lesi O, Faini D, Easterbrook P, Duncombe C, Jordan MR, Matthews PC
  • Lancet Microbe
  • doi: 10.1016/j.lanmic.2025.101076
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• Is health, growth and development impaired in children who are Hepatitis B-exposed but uninfected?
  • Lumley SF, Parker E, Prendergast AJ, Matthews PC
  • PLOS Global Public Health
  • doi: 10.1371/journal.pgph.0004984
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Cancer

• Mesenchymal stromal cells from JAK2 V617F myeloproliferative neoplasms support healthy and malignant hematopoiesis in a humanized scaffold model in vivo.
  • Ferrelli A, Mian S, Piganeau M, Huerga Encabo H, Papazoglou D, D'Agostino G, Mohamad Nor F, Garcia-Albornoz M, Ngo S, Ariza-Mcnaughton L, Morsia E, Della Porta MG, Harrison C, Kordasti S, Bonnet D
  • Hemasphere
  • doi: 10.1002/hem3.70185
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• Spatial organisation of tumour cDC1 states correlates with effector and stem-like CD8+ T cells location.
  • Piot C, Pereira Da Costa M, Biram A, Minutti CM, Lim J, Green M, Mikolajczak A, Jenkins R, Meader L, Buck MD, Cardoso A, Rogers N, Sahai E, Reis e Sousa C
  • European Journal of Immunology
  • doi: 10.1002/eji.70011
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• Preprint: Saturation genome editing of BRCA1 across cell types accurately resolves cancer risk
  • Dace P, Forrester NM, Zanti M, Cubitt L, Terwagne C, Buckley M, van Veen EM, Wilson TS, Scaffidi P, Michailidou K, Findlay GM
  • doi: 10.1101/2025.08.11.25333423

Development and Stem Cells

• Capturing nematic order on tissue surfaces of arbitrary geometry.
  • Eckert J, Andrews TGR, Pollard J, Shen Y, Essebier P, Ladoux B, Lagendijk AK, Priya R, Yap AS, Morris RG
  • Nature Communications
  • doi: 10.1038/s41467-025-62694-x
  • No Figshare PDF

• Variant-specific disruption to notch signalling in PAX6 microphthalmia and aniridia patient-derived hiPSC optic cup-like organoids.
  • Harding P, Owen N, Eintracht J, Cunha DL, Chan B, Rainger J, Moosajee M
  • Biochimica et Biophysica Acta - Molecular Basis of Disease
  • doi: 10.1016/j.bbadis.2025.167869
  • No Figshare PDF

Genes to Cells

• Variant-specific disruption to notch signalling in PAX6 microphthalmia and aniridia patient-derived hiPSC optic cup-like organoids.
  • Harding P, Owen N, Eintracht J, Cunha DL, Chan B, Rainger J, Moosajee M
  • Biochimica et Biophysica Acta - Molecular Basis of Disease
  • doi: 10.1016/j.bbadis.2025.167869
  • No Figshare PDF

• Whole-genome ancestry of an Old Kingdom Egyptian.
  • Morez Jacobs A, Irish JD, Cooke A, Anastasiadou K, Barrington C, Gilardet A, Kelly M, Silva M, Speidel L, Tait F, Williams M, Brucato N, Ricaut F-X, Wilkinson C, Madgwick R, Holt E, Nederbragt AJ, Inglis E, Hajdinjak M, Skoglund P, Girdland-Flink L
  • Nature
  • doi: 10.1038/s41586-025-09195-5
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• Preprint: Developmental changes in the carotid body transcriptome accompanying the maturation of chemosensitivity
  • Hodson EJ, Sugimoto Y, Manamperige RS, Ford SG, Botting-Lawford KJ, Niu Y, Nathan JA, Giussani DA, Ratcliffe PJ
  • doi: 10.1101/2025.08.21.671502

• Preprint: Balanced contractility and adhesion drive polarization in a minimal elastic actomyosin network
  • Messi Z, Raynaud F, Goehring NW, Verkhovsky AB
  • doi: 10.1101/2025.08.26.672435

• Preprint: In situ cryo-electron tomography of vaccinia virus exit from infected cells
  • Hernandez-Gonzalez M, Nans A, Calcraft T, Rosenthal PB, Way M
  • doi: 10.1101/2025.08.20.671218

Host and Pathogen

• Improved resolution of influenza vaccination responses with high-throughput live virus microneutralisation.
  • Adams L, Stevenson-Leggett P, Lee JL, Bazire J, Dowgier G, Hobbs A, Roustan C, Borg A, Carr C, Innocentin S, Webb LMC, Smith C, Bawumia P, Lewis N, O'Reilly N, Kjaer S, Linterman MA, Harvey R, Wu MY, Carr EJ
  • Influenza and Other Respiratory Viruses
  • doi: 10.1111/irv.70140
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• DNGR-1 regulates proliferation and migration of bone marrow dendritic cell progenitors.
  • Cardoso A, Buck MD, Frederico B, Chakravarty P, Schulz O, Lim KHJ, Piot C, Pereira Da Costa M, Giampazolias E, Gasparrini F, Rogers N, Reis e Sousa C
  • Journal of Experimental Medicine
  • doi: 10.1084/jem.20241813
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• Spatial organisation of tumour cDC1 states correlates with effector and stem-like CD8+ T cells location.
  • Piot C, Pereira Da Costa M, Biram A, Minutti CM, Lim J, Green M, Mikolajczak A, Jenkins R, Meader L, Buck MD, Cardoso A, Rogers N, Sahai E, Reis e Sousa C
  • European Journal of Immunology
  • doi: 10.1002/eji.70011
  • PDF

• Humoral, T cell and immune gene expression responses to SARS-CoV-2 vaccination in a small group of children with previous MIS-C
  • Spracklen TF, Day J, Van Der Ross H, Butters C, Benede N, Walters A, Bunjun R, Moyo-Gwete T, Madzivhandila M, Mendelsohn SC, Scriba TJ, Shey M, Burgers WA, Moore PL, Zühlke LJ, Keeton RS, Webb K
  • Vaccine
  • doi: 10.1016/j.vaccine.2025.127461
  • No Figshare PDF

• Targeted CRISPR screens reveal genes essential for Cryptosporidium survival in the host intestine.
  • Watson LC, Sala KA, Bernitz N, Baumgärtel L, Pallett MA, Marzook NB, Straker LC, Peng D, Collinson L, Sateriale A
  • Nature Communications
  • doi: 10.1038/s41467-025-63012-1
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• Preprint: HepB-Boost: Implementation of free of charge healthcare worker hepatitis B testing and vaccination at Kilifi County Referral Hospital, Kenya.
  • Downs L, Tinga L, Andersson M, Matthews PC, Madia J, Moraa B, Gathua L, Tajbhai M-U-A, Kagwanja N, Aliyan N
  • doi: 10.1101/2025.08.27.25334580

• Preprint: Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell
  • Jones D, Belda H, Broncel M, Fuchs G, Anaguano D, Nofal SD, Treeck M
  • doi: 10.7554/elife.107860

Neuroscience

• An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS.
  • Neeves J, Petrić Howe M, Ziff OJ, Callaghan B, Jutzi D, Pal K, Roumeliotis TI, Choudhary J, Isaacs AM, Rigo F, Bennett CF, Ruepp M-D, Patani R
  • Science Advances
  • doi: 10.1126/sciadv.adt4814
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• Preprint: Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
  • Evans JR, Grant-Peters M, Beckwith JS, Toomey CE, Popovic R, Breiter JC, Brenton JW, Fairbrother-Browne A, Strohbuecker S, Lachica J, Rodriguez-Lopez M, Brock EE, Fu B, Nahidiazar L, Lopez-Garcia P, Ferguson R, Saleeb RS, Lucas-Clarke H, Penverne A, D'Sa K, Pang CW, Horrocks MH, Vendruscolo M, Wood N, Lee SF, Ryten M, Gandhi S
  • doi: 10.1101/2025.08.25.671921

Structural and Chemical Biology

• The role of metabolism in shaping enzyme structures over 400 million years.
  • Lemke O, Heineike BM, Viknander S, Cohen N, Li F, Steenwyk JL, Spranger L, Agostini F, Lee CT, Aulakh SK, Berman J, Rokas A, Nielsen J, Gossmann TI, Zelezniak A, Ralser M
  • Nature
  • doi: 10.1038/s41586-025-09205-6
  • PDF

• Preprint: In situ cryo-electron tomography of vaccinia virus exit from infected cells
  • Hernandez-Gonzalez M, Nans A, Calcraft T, Rosenthal PB, Way M
  • doi: 10.1101/2025.08.20.671218