Reviews September 2025 

• Heart of the matter: Neutrophils, cancer, and cardiovascular disease.
  • Ambreen S, Mccarthy A, Hidalgo A, Adrover JM
  • Journal of Experimental Medicine
  • doi: 10.1084/jem.20242402
  • PDF

• Hypoxia-inducible factor 2α: at the interface between oxygen sensing systems in physiology and pathology.
  • Bishop T, Ratcliffe PJ
  • Physiology
  • doi: 10.1152/physiol.00043.2024
  • PDF

• Genetic basis of non-syndromic childhood glaucoma associated with anterior segment dysgenesis: A narrative review
  • Cronbach N, Méjécase C, Moosajee M
  • Pharmaceuticals
  • doi: 10.3390/ph18091352
  • PDF

• Extrachromosomal DNA: shaping the evolutionary dynamics of cancer.
  • Haughey M, Noorani I, Swanton C, Mischel PS, Werner B
  • Trends in Cancer
  • doi: 10.1016/j.trecan.2025.06.004
  • No Figshare pdf

• ATG9 not just an autophagy related protein.
  • Millard E, Tooze SA
  • Journal of Molecular Biology
  • doi: 10.1016/j.jmb.2025.169288
  • PDF

• Nanomechanics at the extracellular matrix-focal adhesion interface
  • Tapia-Rojo R, Garcia-Manyes S
  • Current Opinion in Biomedical Engineering
  • doi: 10.1016/j.cobme.2025.100599
  • No Figshare pdf

Cancer

• Neutrophils drive vascular occlusion, tumour necrosis and metastasis.
  • Adrover JM, Han X, Sun L, Fujii T, Sivetz N, Daßler-Plenker J, Evans C, Peters J, He X-Y, Cannon CD, Ho WJ, Raptis G, Powers RS, Egeblad M
  • Nature
  • doi: 10.1038/s41586-025-09278-3
  • PDF

• DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
  • Gimeno-Valiente F, Castignani C, Larose Cadieux E, Mensah NE, Liu X, Chen K, Chervova O, Karasaki T, Weeden CE, Richard C, Lai S, Martínez-Ruiz C, Lim EL, Frankell AM, Watkins TBK, Stavrou G, Usaite I, Lu W-T, Marinelli D, Saghafinia S, Wilson GA, Dhami P, Vaikkinen H, Steif J, Veeriah S, Hynds RE, Hirst M, Hiley C, Feber A, Deniz Ö, Jamal-Hanjani M, McGranahan N, TRACERx Consortium, Beck S, Demeulemeester J, Tanić M, Swanton C, Van Loo P, Kanu N
  • Nature Genetics
  • doi: 10.1038/s41588-025-02307-x
  • PDF

• MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition.
  • Lueg GA, Zhang J, Faronato M, Gorelik A, Kallemeijn WW, Falciani F, Walton J, Houghton JW, Vannini S, Poon E, Costa BM, Solari R, Carr R, Bell AS, Bartlett EJ, Brzezicha B, Janz M, Chesler L, Calado DP, Tate EW
  • Cell Reports
  • doi: 10.1016/j.celrep.2025.116180
  • PDF

• EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers.
  • Maric M, Segura-Bayona S, Kuthethur R, Takaki T, Borel V, Stanage TH, Ivanov MP, Parnandi N, Hewitt G, Millar R, Fonseca CS, Patel H, Llorian M, Warchal S, Howell M, Chaudhuri AR, Kotsantis P, Boulton SJ
  • Nature Communications
  • doi: 10.1038/s41467-025-63349-7
  • PDF

• Differentiating clinically important interstitial lung abnormalities in lung cancer screening.
  • Selvarajah B, Bhamani A, Azimbagirad M, Ozaltin B, Egashira R, Yamuda D, McCabe J, Smallcombe N, Verghese P, Prendecki R, Creamer A, Dickson JL, Horst C, Tisi S, Hall H, Khaw CR, Mullin ML, Gyertson K, Hacker A-M, Farrelly L, Devaraj A, Nair A, Yuneva M, Navani N, Alexander DC, Chambers RC, Porter J, Hackshaw A, Jenkins G, SUMMIT Consortium, Janes SM, Jacob J
  • BMJ Open Respiratory Research
  • doi: 10.1136/bmjresp-2025-003298
  • PDF

• Preprint: Lactate blocks tertiary lymphoid structure formation by inhibiting B cell chemotaxis
  • Boulat V, Alberts E, Driscoll PC, Hung MS, Cunha A, Quist J, Liu F, Brundin CA, Bhalla A, Avalle L, Rosekilly J, Ryan L, Gillett C, Strom M, Poli V, MacRae JI, Grigoriadis A, Calado DP
  • doi: 10.1101/2025.08.30.673054

• Preprint: SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres
  • Segura-Bayona S, Borel V, Stanage TH, Maric M, Walter M, Oliveira RA, Li S, Idilli AI, Peritore M, Hewitt G, Hekkelman M, Snell DM, Jones ST, Cheshire C, Elezi A, Chakravarty P, Mitter R, Mikolajczak A, Gee HE, Nye E, O'Sullivan RJ, Singhi AD, Brummelkamp TR, Cesare AJ, Boulton SJ
  • doi: 10.1101/2025.09.10.675313

• Preprint: Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity
  • Segura-Bayona S, Maric M, Takaki T, Manova Z, Li S, Stanage TH, Idilli AI, Hewitt G, Ruis P, Millar R, Patel H, Howell S, Kotsantis P, Howell M, Boulton SJ
  • doi: 10.1101/2025.09.22.677761

• Preprint: Cell migration sculpts evolutionary dynamics favouring therapy resistance in lung cancer
  • Bhargava A, Fu X, Bailey S, Naito Y, Mohammadi H, Hynds R, Hooper S, Biswas D, Le Marois A, Kumar S, Alexandrov Y, French PM, McGinty J, Bates PA, Swanton C, Sahai E
  • doi: 10.1101/2025.09.15.675999

• Preprint: Clonal selection supported by single cell DNA sequencing reveals hormonal adaptation and resistance in locally advanced breast cancer during neoadjuvant aromatase inhibition
  • O’Mahony DG, Lesluyes T, Brorson IS, Vernhoff P, Sokolova K, Aure MR, Alnæs GG, Hoøen RM, Sundaram AYM, Theesfeld C, Geisler SB, Sauer T, Bahrami N, Parulkar R, Tahiri A, Lüders T, Troyanskaya O, Vaske C, van Loo P, Geisler J, Kristensen VN
  • doi: 10.1101/2025.09.24.678208

Development and Stem Cells

• Gene network organization, mutation, and selection collectively drive developmental pattern evolvability and predictability
  • Booth H, Hadjivasiliou Z
  • PRX Life
  • doi: 10.1103/q79n-k93j
  • PDF

• Preprint: Morphogen and juxtacrine signalling dynamically integrate to specify cell fates with single-cell resolution
  • Donoghue A, Mosby LS, Lago-Baldaia I, Hodgetts T, Ursu E, Erten Z, Hadjivasiliou Z, Fernandes VM
  • doi: 10.1101/2025.09.15.676088

Genes to Cells

• Cell cycle regulation has shaped replication origins in budding yeast.
  • Lim CT, Miller TCR, Tan KW, Talele S, Early A, East P, Sánchez H, Dekker NH, Costa A, Diffley JFX
  • Nature Structural & Molecular Biology
  • doi: 10.1038/s41594-025-01591-9
  • PDF

• Preprint: SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres
  • Segura-Bayona S, Borel V, Stanage TH, Maric M, Walter M, Oliveira RA, Li S, Idilli AI, Peritore M, Hewitt G, Hekkelman M, Snell DM, Jones ST, Cheshire C, Elezi A, Chakravarty P, Mitter R, Mikolajczak A, Gee HE, Nye E, O'Sullivan RJ, Singhi AD, Brummelkamp TR, Cesare AJ, Boulton SJ
  • doi: 10.1101/2025.09.10.675313

• Preprint: Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity
  • Segura-Bayona S, Maric M, Takaki T, Manova Z, Li S, Stanage TH, Idilli AI, Hewitt G, Ruis P, Millar R, Patel H, Howell S, Kotsantis P, Howell M, Boulton SJ
  • doi: 10.1101/2025.09.22.677761

• Preprint: Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation
  • Olthof AM, Noe Gonzalez MJ, Poulsen NB, Moreno NN, Bautu T, Cugusi S, Svejstrup JQ
  • doi: 10.1101/2025.09.18.677100

• Preprint: Investigations into fission yeast chromosome size determinants
  • Wu P-S, Fallesen T, Uhlmann F
  • doi: 10.1101/2025.09.15.676266

Host and Pathogen

• Third exposure to COVID-19 infection or vaccination differentially impacts T cell responses.
  • Ahimbisibwe G, Greenwood D, Wilkinson KA, Gahir J, Townsley H, Miah M, Bawumia P, Chaloner C, Levi D, Hobson P, Riddell A, Hobbs A, Dowgier G, Penn R, Sanderson T, Stevenson-Leggett P, Daley O, Bazire J, Harvey R, Fowler AS, Smith C, Miranda M, O'Reilly N, Warchal S, Ambrose K, Strange A, Kelly G, Kjaer S, Legacy Investigators, Williams B, Libri V, Gamblin S, Gandhi S, Swanton C, Bauer DLV, Wilkinson RJ, Carr EJ, Wall EC
  • Journal of Infection
  • doi: 10.1016/j.jinf.2025.106598
  • PDF

• Evaluation of Hepatitis B core related antigen (HBcrAg) as a biomarker in cohorts from the United Kingdom and South Africa.
  • Downs LO, Delphin M, van Schalkwyk M, Hugo S, Lumley SF, Waddilove E, Wang T, Martin J, de Lara C, Babbs A, Andersson MI, Glashoff RH, Ansari MA, Agarwal K, Dusheiko G, Taljaard J, Preiser W, Barnes E, Kelly G, Carey I, Shimakawa Y, Maponga T, Matthews PC
  • Journal of Infection
  • doi: 10.1016/j.jinf.2025.106601
  • PDF

• HIV PrEP programmes as a framework for diagnosing and treating HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa
  • Sukali G, Busang J, Dreyer J, Khoza T, Delphin M, Okesola N, Herbst C, Waddilove E, Upton J, Seeley J, Iwuji C, Anderson M, Matthews PC, Shahmanesh M
  • Journal of Virus Eradication
  • doi: 10.1016/j.jve.2025.100600
  • PDF

• Preprint: Streptococcus pneumoniae accessory capsular genes modulate fitness, pathogenicity and immune evasion
  • Chana JM, Flynn H, Kima S, Demetriou H, Ramos-Sevillano E, Alsari A, Roalfe L, Ercoli G, Kalizang’oma A, Browne C, Chaguza C, French N, Brown J, Goldblatt D, Carvalho LPSD, Heyderman RS
  • doi: 10.1101/2025.09.11.675585

• Preprint: TACI regulates marginal zone B cell development
  • Luff DH, Vanes L, Boeing S, Tybulewicz VLJ
  • doi: 10.1101/2025.09.05.674478

• Preprint: Mechanisms for cross–neutralisation of diverse bat sarbecoviruses
  • Upadhyay A, Seow J, Alguel Y, Newman J, Thakur N, Hay AL, Tam JCH, Nans A, Orton RJ, Bailey D, Cherepanov P, Doores KJ
  • doi: 10.1101/2025.09.17.674891

Neuroscience

• Preprint: Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context
  • Park SY, Sheridan A, An B, Jarvis E, Lyudchik J, Patton W, Axup JY, Chan SW, Damstra HGJ, Leible D, Leung KS, Magno CA, Meeran A, Michalska JM, Rieger F, Wang C, Wu M, Church GM, Funke J, Huffman T, Leeper KGC, Truckenbrodt S, Winnubst J, Kornfeld JMR, Boyden ES, Rodriques SG, Payne AC
  • doi: 10.1101/2025.09.26.678648

• Preprint: Critical point drying of brain tissue for X-ray phase contrast imaging
  • Khan S, Albers J, Vorobyev A, Zhang Y, Reichmann J, Svetlove A, de Marco F, Denisova K, Yang Y, Seichepine F, Douglas JO, Duke E, Cloetens P, Pacureanu A, Schaefer AT, Bosch C
  • doi: 10.1101/2025.09.02.673701

Structural and Chemical Biology

• Dynamic laboratory x-ray phase-contrast microtomography with structure-based prior regularisation.
  • Allan H, Partridge T, Jacob J, Endrizzi M
  • Measurement Science and Technology
  • doi: 10.1088/1361-6501/ae01c8
  • No Figshare pdf

• An automated workflow to address proteome complexity and the large search space problem in proteomics and HLA-I immunopeptidomics.
  • Horokhovskyi Y, Roetschke HP, Cormican JA, Pašen M, Garazhian S, Mishto M, Liepe J
  • Molecular & Cellular Proteomics
  • doi: 10.1016/j.mcpro.2025.101039
  • PDF

• Cell cycle regulation has shaped replication origins in budding yeast.
  • Lim CT, Miller TCR, Tan KW, Talele S, Early A, East P, Sánchez H, Dekker NH, Costa A, Diffley JFX
  • Nature Structural & Molecular Biology
  • doi: 10.1038/s41594-025-01591-9
  • PDF

• Preprint: A nanopathology pipeline for clinical research across scales using human tissue
  • Burrell A, Lawson M, Ronchi P, Xiong X, Albers J, McLean A, Willicombe M, Moran L, Hounsome J, Jones M, Ross G, de Folter J, Hartley M, Uhlmann V, Strange A, Schwab Y, Duke E, Roufosse C, Collinson L
  • doi: 10.1101/2025.08.29.25334660

• Preprint: Proteome-wide target identification using reactive metallo-scaffolds (r-mS): A platform for metallodrug discovery
  • Waters JE, Biggs GS, Wilders H, Cawood EE, Bailey J, Kintzel M, Maslen S, Yip YM, Wakley M, Redmond J, Skehel JM, House D, Bush J, Hess J
  • doi: 10.26434/chemrxiv-2025-gvz2g

• Preprint: Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics
  • Patel K, Mohanty B, Norman A, Franck C, Pachl P, Yang L, Jing X, Reid XJ, Walshe JL, Solomon P, Tran DH, Ford D, Low JKK, Wilkinson-White L, Passioura T, Payne RJ, Suga H, Walport LJ, Mackay JP
  • doi: 10.1101/2025.09.24.678353