Reviews July 2025 

• Clinical trials for Hepatitis Delta Virus in the WHO African region: A neglected virus among neglected viruses.
  • Delphin M, Campbell J, Verrier ER, Anderson M, Sukali G, Maponga T, Stockdale A, Matthews PC
  • Journal of Infection
  • doi: 10.1016/j.jinf.2025.106514
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• Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis.
  • Leung MM, Swanton C, McGranahan N
  • Nature Reviews Genetics
  • doi: 10.1038/s41576-025-00825-2
  • No Figshare pdf

• Is the bone marrow microenvironment the hidden catalyst in malignant haematopoiesis?
  • Mian SA, Ngo S, Bonnet D
  • Leukemia
  • doi: 10.1038/s41375-025-02630-6
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• Measuring HLA disruption using MHC Hammer.
  • Puttick C
  • Nature Reviews Cancer
  • doi: 10.1038/s41568-025-00822-x
  • No Figshare pdf

• The role of ETS2 in macrophage inflammation.
  • Stankey CT, Lee JC
  • DNA and Cell Biology
  • doi: 10.1089/dna.2025.0064
  • No Figshare pdf

Cancer

• A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adults.
  • Maponga TG, McNaughton AL, Campbell C, de Cesare M, Mokaya J, Lumley SF, Bonsall D, Ip CLC, Chai H, Van Rensburg C, Glashoff RH, Waddilove E, Preiser W, Blackard JT, Ansari MA, Kramvis A, Andersson MI, Matthews PC
  • Annals of Hepatology
  • doi: 10.1016/j.aohep.2024.101763
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• p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis
  • Wittke CI, Cheung EC, Athineos D, Clements N, Butler L, Hughes M, Morrison V, Watt DM, Blyth K, Vousden KH, Humpton TJ
  • JHEP Reports
  • doi: 10.1016/j.jhepr.2025.101397
  • No Figshare pdf

• Preprint: Differential chromatin response to retinoic acid in neuroblastoma according to type of ATRX mutation
  • Lorenzi F, Shipley M, Deane L, Goldstone R, Tandon V, Martins da Costa B, Greenslade K, Barker K, Nemati F, Bellini A, Schleiermacher G, Chesler L, Guillemot F, George SL
  • doi: 10.1101/2025.07.14.664731

• Preprint: An optimised computational approach for the identification of somatic structural variants in cancer
  • Waise S, Mensah N, Lesluyes T, Demeulemeester J, Flanagan A, Pillay N, Van Loo P
  • doi: 10.1101/2025.07.01.662575

Development and Stem Cells

• Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
  • Gharibi B, Inge OCK, Rodriguez-Hernandez I, Driscoll PC, Dubois C, Jiang M, Howell M, Skehel JM, Macrae JI, Santos SDM
  • Cell
  • doi: 10.1016/j.cell.2025.04.025
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• Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst.
  • Simon CS, Mccarthy A, Woods L, Staneva D, Prok M, Salehin N, Lea G, Huang Q, Linneberg-Agerholm M, Faulkner A, Papathanasiou A, Elder K, Snell P, Christie L, Garcia P, Shaikly V, Taranissi M, Choudhary M, Herbert M, Hanna CW, Brickman JM, Niakan KK
  • Nature Communications
  • doi: 10.1038/s41467-025-61830-x
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• Preprint: Boundary constraints can determine pattern emergence
  • Loo YT, Chen J, Harrison R, Rito T, Theis S, Charras G, Briscoe J, Saunders TE
  • doi: 10.1101/2025.07.21.665949

Genes to Cells

• Nonredundant roles of topoisomerase 2α and 2β in the cytosolic replication of vaccinia virus.
  • Dalla Rosa I, Kent L, Way M
  • Nucleic Acids Research
  • doi: 10.1093/nar/gkaf566
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• Spatiotemporal orchestration of mitosis by cyclin-dependent kinase.
  • Kapadia N, Nurse P
  • Nature
  • doi: 10.1038/s41586-025-09172-y
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• p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis
  • Wittke CI, Cheung EC, Athineos D, Clements N, Butler L, Hughes M, Morrison V, Watt DM, Blyth K, Vousden KH, Humpton TJ
  • JHEP Reports
  • doi: 10.1016/j.jhepr.2025.101397
  • PDF

• Preprint: ​​​Lonafarnib partially reverses cardiac senescence in human and mouse progeria models via autophagy activation
  • Monteiro LM, Pitrez PR, Correia-Santos S, Dark N, Santinha D, Aveleira C, Townsend M, Taylor J, Nissan X, Sardão V, Cortes L, Mitter R, Marino A, Sousa-Soares C, Ribeiro R, Smith JC, Logarinho E, Ori A, Bernardo AS, Ferreira L
  • doi: 10.1101/2025.06.27.661680

• Preprint: Kandinsky: enabling neighbourhood analysis of spatial omics data for functional insights on cell ecosystems
  • Andrei P, Grieco M, Acha-Sagredo A, Dhami P, Fung K, Rodriguez-Justo M, Cereda M, Ciccarelli FD
  • doi: 10.1101/2025.07.10.664141

• Preprint: Control of CDK activity and the cell cycle by CKS proteins
  • Curran JF, Basu S, Auchynnikava T, Nurse P
  • doi: 10.1101/2025.07.04.663185

• Preprint: Multi-scale molecular imaging of human cells reveals COPI and COPII vesicles at ER exit sites
  • Downes KW, Flood JR, Nans A, Van der Verren S, Audhya A, Zanetti G
  • doi: 10.1101/2025.07.29.667472

Host and Pathogen

• Slow virologic control but strong immune and metabolic recovery with dolutegravir-anchored therapy in an HIV cohort in Ghana
  • Appeaning M, Magomere E, Abotsi AM, Amoako NAY, Kouffie KE, Tetteh BE, Quist BND, Tchopba CN, Ansa GA, Bonney EY, Quashie PK
  • Virology Journal
  • doi: 10.1186/s12985-025-02873-w
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• Macrocyclic peptide probes for immunomodulatory protein CD59: Potent modulators of bacterial toxin activity and antibody-dependent cytotoxicity.
  • Bickel JK, Ahmed AIS, Pidd AB, Morgan RM, McAllister TE, Horrell S, Couves EC, Nagaraj H, Bartlett EJ, El Omari K, Kawamura A, Bubeck D, Tate EW
  • Angewandte Chemie International Edition
  • doi: 10.1002/anie.202422673
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• A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adults.
  • Maponga TG, McNaughton AL, Campbell C, de Cesare M, Mokaya J, Lumley SF, Bonsall D, Ip CLC, Chai H, Van Rensburg C, Glashoff RH, Waddilove E, Preiser W, Blackard JT, Ansari MA, Kramvis A, Andersson MI, Matthews PC
  • Annals of Hepatology
  • doi: 10.1016/j.aohep.2024.101763
  • PDF

• Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs.
  • Panagi I, Muench JH, Ronneau A, Diaz-Del-Olmo I, Aliyath A, Yu X-J, Mak H, Jin E, Zeng J, Esposito D, Jennings E, Pillay TD, Günster RA, Maslen SL, Rittinger K, Thurston TLM
  • EMBO Reports
  • doi: 10.1038/s44319-025-00472-y
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• Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses.
  • Plowman T, Hofland T, Hall C, Thompson R, Pape J, Ng KW, Doglio L, Kassiotis G
  • Science Immunology
  • doi: 10.1126/sciimmunol.adr1105
  • No Figshare pdf

Neuroscience

• Mislocalization of nucleic acids is a convergent and targetable mechanism in Alzheimer's disease and frontotemporal dementia.
  • Hung C, Llorian M, Pal K, Livesey FJ, Choudhary J, Roumeliotis TI, Patani R
  • Cell reports
  • doi: 10.1016/j.celrep.2025.115867
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• Preprint: Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits
  • Becalick A, Blot A, Strom M, Znamenskiy P
  • doi: 10.1101/2025.07.16.665048

• Preprint: Topographic alignment of auditory inputs to the visual cortex
  • Egea-Weiss A, Turner-Bridger B, Viduolyte A, Marianelli E, Znamenskiy P, Iacaruso MF
  • doi: 10.1101/2025.07.29.667237

Structural and Chemical Biology

• The molecular landscape of cellular metal ion biology.
  • Aulakh SK, Lemke O, Szyrwiel L, Kamrad S, Chen Y, Hartl J, Mülleder M, Nielsen J, Ralser M
  • Cell Systems
  • doi: 10.1016/j.cels.2025.101319
  • No Figshare pdf

• The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells
  • Bertolin AP, Canal B, Yekezare M, Early A, Zeng J, Instrell R, Howell M, Diffley JFX
  • Molecular Cell
  • doi: 10.1016/j.molcel.2025.06.002
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• The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks
  • Canal B, Bertolin AP, Lee GC, Drury LS, Minamino M, Diffley JFX
  • Molecular Cell
  • doi: 10.1016/j.molcel.2025.06.001
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• Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs.
  • Panagi I, Muench JH, Ronneau A, Diaz-Del-Olmo I, Aliyath A, Yu X-J, Mak H, Jin E, Zeng J, Esposito D, Jennings E, Pillay TD, Günster RA, Maslen SL, Rittinger K, Thurston TLM
  • EMBO Reports
  • doi: 10.1038/s44319-025-00472-y
  • PDF

• Discovery and validation of a novel class of necroptosis inhibitors targeting RIPK1.
  • Soday L, Seripracharat C, Gray JL, Luz AFS, Howard RT, Singh R, Burden TJ, Bernardini E, Mateus-Pinheiro M, Petersen J, Gunnarsson A, Gunnarsson J, Aagaard A, Sjögren T, Maslen S, Bartlett EJ, Iles AF, Smith DM, Scott JS, Skehel M, Davis AM, Ressurreição
  • ACS Chemical Biology
  • doi: 10.1021/acschembio.5c00112
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• Preprint: Light-activated metal-dependent protein degradation (LAMP-D): A heterobifunctional ruthenium(II) photosensitizer targeting New Delhi metallo-β-lactamase 1
  • Stevens-Cullinane L, Rees TW, Evans C, Ho P-Y, Kintzel M, Yip YM, Jia R, Bailey J, Clifford E, Alam R, Maslen S, Mouilleron S, Pasquier A, Song O-R, Warchal S, Redmond J, Howell M, Kjaer S, Skehel M, Müller MM, Johnson EO, Roessler MM, Hess J
  • doi: 10.26434/chemrxiv-2025-jx9jt

• Preprint: A new material constant of DNA is the major determinant of looping dynamics
  • Pobegalov G, Molodtsov M, Khatri BS
  • doi: 10.1101/2025.07.10.664086