Reviews June 2025 

• Structures and mechanisms of AAA+ protein complexes in DNA processing.
  • Carver A, Zhang B, Zhang X
  • Current Opinion in Structural Biology
  • doi: 10.1016/j.sbi.2025.103056
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• Compromised epigenetic robustness in cancer: fueling evolution, exposing weakness.
  • Wilson TS, Scaffidi P
  • Trends in Cancer
  • doi: 10.1016/j.trecan.2025.02.001
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Papers June 2025

• The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound.
  • Belda H, Bradley D, Christodoulou E, Nofal SD, Broncel M, Jones D, Davies H, Bertran MT, Purkiss AG, Ogrodowicz RW, Joshi D, O'Reilly N, Walport L, Powell A, House D, Kjaer S, Claessens A, Landry CR, Treeck M
  • Nature Microbiology
  • doi: 10.1038/s41564-025-02017-4
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• Dominance rank inference in mice via chemosensation
  • Borak N, Wai P, Rodriguez Villamayor P, Claxton PM, Liang S, Kohl J
  • Current Biology
  • doi: 10.1016/j.cub.2025.04.063
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• Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer's disease.
  • Caramello A, Fancy N, Tournerie C, Eklund M, Chau V, Adair E, Papageorgopoulou M, Willumsen N, Jackson JS, Hardy J, Matthews PM
  • Nature Communications
  • doi: 10.1038/s41467-025-60328-w
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• PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin
  • Fedoryshchak RO, El-Bouri K, Joshi D, Mouilleron S, Treisman R
  • eLife
  • doi: 10.7554/elife.103403.3
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• Discordance between measures of Mycobacterium tuberculosis sensitization and type 2 diabetes mellitus in the United States (NHANES): A population-based cohort study.
  • Magodoro IM, Wilkinson KA, Claggett BL, Ntusi NAB, Siedner M MJ, Wilkinson RJ
  • Journal of Infection
  • doi: 10.1016/j.jinf.2025.106496
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• Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination.
  • McPhie KA, Esposito D, Pettinger J, Norman D, Werner T, Mathieson T, Bush JT, Rittinger K
  • Chemical Science
  • doi: 10.1039/d5sc01540e
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• Sequential transcriptional programs underpin activation of hippocampal stem cells.
  • Rigo P, Ahmed-de-Prado S, Johnston RL, Choudhury C, Guillemot F, Harris L
  • Science Advances
  • doi: 10.1126/sciadv.adu4523
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• A Drosophila holidic diet optimized for growth and development.
  • Sorge S, Girard V, Lampe L, Tixier V, Weaver A, Higgins T, Gould AP
  • Developmental Cell
  • doi: 10.1016/j.devcel.2025.01.008
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• Investigation of influenza A(H5N1) virus neutralization by quadrivalent seasonal vaccines, United Kingdom, 2021–2024
  • Stevenson-Leggett P, Adams L, Greenwood D, Lofts A, Libri V, Williams B, Gandhi S, Swanton C, Gamblin S, Carr EJ, Harvey R, Lewis NS, Wu MY, Wall EC
  • Emerging Infectious Diseases
  • doi: 10.3201/eid3106.241796

Preprints June 2025

• Microglial response to amyloid-β pathology is modulated by X chromosome dosage
  • Davis E, Gatto N, Meleckyte R, Varsally W, Mitchener VFT, Thackray MJ, Fiers M, De Strooper B, Turner JMA, Arancibia-Cárcamo IL
  • doi: 10.21203/rs.3.rs-6558560/v1

• Influenza A virus polymerase co-opts distinct sets of host proteins for RNA transcription or replication
  • Rasmussen AB, Swann OC, Sukhova K, Liu N, Brown MD, Martin-Sancho L, Sheppard CM, Barclay WS
  • doi: 10.1101/2025.06.06.658254

• SARS-CoV-2 antibody immunity across three continents: the West Africa, West Indies, West London Consortium
  • Greenwood D, Hague O, Kwesi-Maliepaard EM, Redman SA, Crick Serology Consortium, The HERITAGE study team, Legacy Investigators, WINDFall Study Team, WWW Consortium Team, Scott F, Anzinger JJ, Awandare G, Bauer DLV, Bediako Y, Carr EJ, Carrington CVF, Kucharski A, Quashie PK, Wall EC, Wu MY
  • doi: 10.1101/2025.06.13.25329588

• A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics
  • Autorino C, Khoromskaia D, Harari L, Floris E, Booth H, Pallares-Cartes C, Petrasiunaite V, Dorrity M, Corominas-Murtra B, Hadjivasiliou Z, Petridou N
  • doi: 10.1101/2025.06.06.658228

• Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer model
  • McCluney S, Park D, Miller DSJ, Mehić M, Bloxham RD, Vries ED, Wang X, Boeing S, D'Antonio L, Wieteska Ł, Pyeatt G, Strohbuecker S, Chakravarty P, De Oliveira TM, Wilkinson RW, Hyvönen M, Hunt J, Hill CS
  • doi: 10.1101/2025.06.13.659133

• Overnight circuit remodelling drives juvenile alloparental care
  • Jamieson BB, Chen MX, Liang S, El Rasheed LSH, Chattey GMK, Kohl J
  • doi: 10.1101/2025.06.13.659524

• Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes
  • Goldsworthy S, Fertan E, Dyal P, Domoney S, Livesey F, Klenerman D, Patani R, Hung C
  • doi: 10.1101/2025.05.27.656416

• Cross-species comparative connectomics reveals the evolution of an olfactory circuit
  • Roberts RJV, Giez C, Dhawan S, Pang S, Randel N, Lu Z, Gong H, Dekens L, DiFrisco J, Xu CS, Hess HF, Zlatic M, Cardona A, Prieto-Godino LL
  • doi: 10.1101/2025.06.11.659158

• Multimodal profiling unveils a reversible basal-like breast cancer cell state resistant to AKT inhibition
  • Ratcliffe CDH, Sparks H, Boezio GLM, Alexandrov Y, Jenkins RP, Le Marois A, Soro-Barrio P, Lee R, Strohbuecker S, Joshi S, Ellis JK, Fortier A-M, Gustafsson N, Cunha AC, Park M, MacRae JI, Serio A, Briscoe J, Riddell A, Barry ST, Dunsby C, Sahai E
  • doi: 10.1101/2025.06.06.658331

• VISIBLE: An imaging-driven system for sampling, biofabrication, and manipulation of complex biological models
  • Joshi S, Moreno-Gonzalez C, Suklai P, Carraro E, Ratcliffe CDH, Boezio GLM, Konstantinou G, Hagemann C, Kavanagh T, Ameer-beg S, Imbert A, Sahai E, Tedesco FS, Serio A
  • doi: 10.1101/2025.06.12.659321

• Beneficial and detrimental consequences of AHR activation in intestinal infection
  • Diaz OE, Zhou L, Barrington C, Lindquist D, Graelmann F, Wincent E, Stockinger B
  • doi: 10.1101/2025.05.28.656570

• Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies
  • Moore DP, Steele-Stallard HB, Pinton L, Lionello VM, Rossi L, Aghaeipour A, Jalal S, Wong CTY, Clara-Hwang A, Bonne G, Zammit PS, Tedesco FS
  • doi: 10.1101/2025.06.22.660928

• MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression
  • Nielsen JC, Benito-Jardon M, Petrela NC, Diring J, Bellamy S, Treisman R
  • doi: 10.1101/2025.06.06.657372

• SARS-CoV-2 envelope protein induces LC3 lipidation via the V-ATPase-ATG16L1 axis
  • Figueras-Novoa C, Timimi L, Marcassa E, Taveira-Marques R, Adams L, Jiang M, Wu M, Montaner B, Ng K, De Lorenzo G, Furnon W, Cowton VM, Upfold N, Kassiotis G, Harvey R, Patel AH, Howell M, Ulferts R, Beale R
  • doi: 10.1101/2025.06.12.659257

• Impact of first SARS-CoV-2 infection variant on serological responses against Omicron: findings from the SIREN study
  • Insalata F, Atti A, Carr EJ, Otter AD, SIREN study group, Foulkes S, Dowgier G, Hobbs A, Wu MY, Hopkins S, Charlett A, Beale R, Hall VJ
  • doi: 10.1101/2025.06.02.25328497