Reviews May 2025 

• Amyotrophic lateral sclerosis caused by TARDBP mutations: from genetics to TDP-43 proteinopathy.
  • Balendra R, Sreedharan J, Hallegger M, Luisier R, Lashuel HA, Gregory JM, Patani R
  • Lancet Neurology
  • doi: 10.1016/S1474-4422(25)00109-7

• Repeat expansion disorders.
  • Chen Z, Morris HR, Polke J, Wood NW, Gandhi S, Ryten M, Houlden H, Tucci A
  • Practical Neurology
  • doi: 10.1136/pn-2023-003938
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• Clinical, metabolic and immune interaction between tuberculosis and diabetes mellitus: implications and opportunities for therapies.
  • Magodoro I, Kotze L, Stek CJ, West A, Le Roux A, Sobratee N, Taliep A, Hamada Y, Dave JA, Rangaka MX, Parihar SP, Wilkinson RJ
  • Expert Opinion on Pharmacotherapy
  • doi: 10.1080/14656566.2025.2508904

• Single-molecule localization microscopy as a tool to quantify di/oligomerization of receptor tyrosine kinases and G protein-coupled receptors
  • Sharrocks KL, Swaih AM, Hanyaloglu AC
  • Molecular Pharmacology
  • doi: 10.1016/j.molpha.2025.100033
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• Obesity, white adipose tissue and cancer.
  • Solsona-Vilarrasa E, Vousden KH
  • FEBS Journal
  • doi: 10.1111/febs.17312
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Papers May 2025

• Growth of the maternal intestine during reproduction.
  • Ameku T, Laddach A, Beckwith H, Milona A, Rogers LS, Schwayer C, Nye E, Tough IR, Thoumas J-L, Gautam UK, Wang Y-F, Jha S, Castano-Medina A, Amourda C, Vaelli PM, Gevers S, Irvine EE, Meyer L, Andrew I, Choi KL, Patel B, Francis AJ, Studd C, Game L, Young G, Murphy KG, Owen B, Withers DJ, Rodriguez-Colman M, Cox HM, Liberali P, Schwarzer M, Leulier F, Pachnis V, Bellono NW, Miguel-Aliaga I
  • Cell
  • doi: 10.1016/j.cell.2025.02.015
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• PP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA Pol II transcription termination.
  • Erickson B, Fedoryshchak R, Fong N, Sheridan R, Larson KY, Saviola AJ, Mouilleron S, Hansen KC, Treisman R, Bentley DL
  • Cell Reports
  • doi: 10.1016/j.celrep.2025.115564

• 'They're creepy creatures with human-like features': children's experiences of visual hallucinations in Charles Bonnet syndrome-a qualitative study.
  • Jones L, Ditzel-Finn L, McDonald L, Moosajee M
  • Archives of Disease in Childhood
  • doi: 10.1136/archdischild-2024-327811
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• De novo assembly of plasmodium interspersed repeat (pir) genes from Plasmodium vivax RNAseq data suggests geographic conservation of sub-family transcription.
  • Little TS, Cunningham DA, Christophides GK, Reid AJ, Langhorne J
  • BMC Genomics
  • doi: 10.1186/s12864-025-11752-1
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• Retroelement co-option disrupts the cancer transcriptional programme.
  • Loong J, Thompson R, Hall C, Doglio L, Pape J, Plowman T, Kassiotis G
  • Genome Medicine
  • doi: 10.1186/s13073-025-01479-9
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• Meru co-ordinates spindle orientation with cell polarity and cell cycle progression.
  • Mclellan MM, Aerne BL, Banerjee Dhoul JJ, Holder MV, Auchynnikava T, Tapon N
  • EMBO Journal
  • doi: 10.1038/s44318-025-00420-5
  • PDF

• Effects of M. tuberculosis and HIV-1 infection on in vitro blood-brain barrier function.
  • Proust A, Wilkinson KA, Wilkinson RJ
  • Journal of Neuroinflammation
  • doi: 10.1186/s12974-025-03467-7
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• Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer.
  • Rix B, Chauhan R, Masoumi Z, Grönroos E, Brain CE, Ogunbiyi OK, Swarbrick K, Swanton C, Bonnet D, Kurzawinski TR, Izatt L, McDonald NQ, Grey W
  • npj Precision Oncology
  • doi: 10.1038/s41698-025-00919-4
  • PDF

• Cryptosporidium modifies intestinal microvilli through an exported virulence factor.
  • Rodrigues E, Pallett MA, Straker LC, Mkandawire TT, Sala K, Collinson L, Sateriale A
  • Cell Host and Microbe
  • doi: 10.1016/j.chom.2025.04.001
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• Elevated Visual Crowding in CRB1-Associated Retinopathies: Understanding Functional Visual Deficits Using Child-Friendly Computerized Testing.
  • Rodriguez-Martinez AC, Tailor-Hamblin VK, Higgins BE, Jones PR, Dekker TM, Henderson RH, Greenwood JA, Moosajee M
  • Investigative Ophthalmology and Visual Science
  • doi: 10.1167/iovs.66.5.32

• An ISR-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation.
  • Román-Trufero M, Kleijn IT, Blighe K, Zhou J, Saavedra-García P, Gaffar A, Christoforou M, Bellotti A, Abrahams J, Atrih A, Lamont D, Gierlinski M, Jayaprakash P, Michel AM, Aboagye EO, Yuneva M, Masson GR, Shahrezaei V, Auner HW
  • Life Science Alliance
  • doi: 10.26508/lsa.202403014
  • PDF

• Fatal intracranial haemorrhage shortly after belzutifan initiation in von Hippel-Lindau (VHL) disease-associated haemangioblastoma.
  • Shepherd STC, Kelly-Morland C, Drage S, Brady AF, Macwana R, Pickering L, Larkin J, Hill P, Turajlic S
  • ESMO Open
  • doi: 10.1016/j.esmoop.2025.105109

• Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells.
  • Sheridan D, Chakravarty P, Golan G, Shiakola Y, Olsen J, Burnett E, Galichet C, Fiordelisio T, Mollard P, Melamed P, Lovell-Badge R, Rizzoti K
  • Nature Communications
  • doi: 10.1038/s41467-025-59495-7
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• Baricitinib treatment in RNU7‐1‐associated Aicardi–Goutières syndrome in a South African child: A case report
  • Spracklen TF, Akhalwaya S, Ackermann S, Uggenti C, Seabra L, Crow YJ, Webb K
  • American Journal of Medical Genetics, Part A
  • doi: 10.1002/ajmg.a.63978
  • PDF

• Ancient Borrelia genomes document the evolutionary history of louse-borne relapsing fever.
  • Swali P, Booth T, Tan CCS, McCabe J, Anastasiadou K, Barrington C, Borrini M, Bricking A, Buckberry J, Büster L, Carlin R, Gilardet A, Glocke I, Irish JD, Kelly M, King M, Petchey F, Peto J, Silva M, Speidel L, Tait F, Teoaca A, Valoriani S, Williams M, Madgwick R, Mullan G, Wilson L, Cootes K, Armit I, Gutierrez MG, van Dorp L, Skoglund P
  • Science
  • doi: 10.1126/science.adr2147

• Structural plasticity of Plasmodium falciparum plasmepsin X to accommodate binding of potent macrocyclic hydroxyethylamine inhibitors.
  • Withers-Martinez C, George R, Ogrodowicz R, Kunzelmann S, Purkiss AG, Kjaer S, Walker PA, Kovada V, Jirgensons A, Blackman MJ
  • Journal of Molecular Biology
  • doi: 10.1016/j.jmb.2025.169062
  • PDF

Preprints May 2025

• Dynamic landscape analysis of cell fate decisions: Predictive models of neural development from single-cell data
  • Fontaine M, Delas MJ, Saez M, Maizels RJ, Finnie E, Briscoe J, Rand DA
  • doi: 10.1101/2025.05.28.656648

• MitoTracker transfers from astrocytes to neurons independently of mitochondria
  • Hole KL, Norkett R, Russell E, Strom M, Howden JH, Corbett NJ, Brownlees J, Devine MJ
  • doi: 10.1101/2025.05.27.655523

• The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis
  • Roeselová A, Shivakumaraswamy S, Jurkeviciute G, He JZ, Auburger J, Schmitt JL, Kramer G, Bukau B, Enchev RI, Balchin D
  • doi: 10.1101/2025.05.27.656346

• Triply responsive control of anion/cation transport with an artificial ion channel responsive to multiple stimuli
  • Malla JA, Fenton KJ, Bellamkonda A, Fidler SI, Wallace MI, McTernan CT
  • doi: 10.26434/chemrxiv-2025-sbp1x

• The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice
  • Calleja V, Henry JC, Cobbaut M, Sewell J, Rizzoti K, Houghton F, Boeing S, Anyanwu N, Varsani-Brown S, Snoeks T, Suárez-Bonnet A, Priestnall SL, McDonald NQ, Cameron AJM, Parker PJ
  • doi: 10.1101/2025.05.28.656646

• Conformational dynamics of the bacterial E3 ligase SspH1
  • Kennedy CR, Esposito D, House D, Rittinger K
  • doi: 10.1101/2025.05.12.653404

• Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2
  • Kennedy CR, McPhie KA, Vuorinen A, Dudley-Fraser J, Esposito D, Maslen S, Pettinger J, Skehel JM, Bush J, House D, Rittinger K
  • doi: 10.26434/chemrxiv-2025-8ppqz

• Mice discriminate odour source distance via sub-sniff temporal features of odour plumes
  • Marin AC, Harris JJ, Dasgupta D, Erskine A, Warner TPA, Schaefer AT, Ackels T
  • doi: 10.1101/2025.05.14.653752

• Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell
  • Jones D, Belda H, Fuchs G, Anaguano D, Nofal SD, Treeck M
  • doi: 10.1101/2025.05.14.653932

• PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin
  • Fedoryshchak RO, El-Bouri K, Joshi D, Mouilleron S, Treisman R
  • doi: 10.7554/elife.103403.2

• RAD51AP1 is a versatile RAD51 modulator
  • Kuhlen L, Argunhan B, Liang P, Zhong J, Masino L, Zhang X
  • doi: 10.1101/2025.05.24.655746