Papers February 2025

• A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer
  • Acha-Sagredo A, Andrei P, Clayton K, Taggart E, Antoniotti C, Woodman CA, Afrache H, Fourny C, Armero M, Moinudeen HK, Green M, Bhardwaj N, Mikolajczak A, Rodriguez-Lopez M, Crawford M, Connick E, Lim S, Hobson P, Linares J, Ignatova E, Pelka D, Smyth EC, Diamantis N, Sosnowska D, Carullo M, Ciraci P, Bergamo F, Intini R, Nye E, Barral P, Mishto M, Arnold JN, Lonardi S, Cremolini C, Fontana E, Rodriguez-Justo M, Ciccarelli FD
  • Cancer Cell
  • doi: 10.1016/j.ccell.2024.12.008
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• WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses.
  • Biggs O'May J, Vanes L, de Boer LL, Lewis DA, Hartweger H, Kunzelmann S, Hayward D, Llorian M, Köchl R, Tybulewicz VLJ
  • Nature Communications
  • doi: 10.1038/s41467-025-56778-x
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• Biological agency: a concept without a research program.
  • DiFrisco J, Gawne R
  • Journal of Evolutionary Biology
  • doi: 10.1093/jeb/voae153
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• An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast.
  • Libby ARG, Rito T, Radley A, Briscoe J
  • Development
  • doi: 10.1242/dev.204591
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• Oncogenic PIK3CA corrupts growth factor signaling specificity.
  • Madsen RR, Le Marois A, Mruk ON, Voliotis M, Yin S, Sufi J, Qin X, Zhao SJ, Gorczynska J, Morelli D, Davidson L, Sahai E, Korolchuk VI, Tape CJ, Vanhaesebroeck B
  • Molecular Systems Biology
  • doi: 10.1038/s44320-024-00078-x
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• Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling
  • Wieteska Ł, Taylor AB, Punch E, Coleman JA, Conway IO, Lin Y-F, Byeon C-H, Hinck CS, Krzysiak T, Ishima R, López-Casillas F, Cherepanov P, Bernard DJ, Hill CS, Hinck AP
  • Nature Communications
  • doi: 10.1038/s41467-025-56796-9
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Preprints February 2025

• Enhancing reproducibility through bioimage analysis: The significance of effect sizes and controls
  • Barry DJ, Marcotti S, Gerontogianni L, Kelly G
  • doi: 10.1101/2025.02.10.637409

• Non-redundant roles of topoisomerase 2α and 2β in the cytosolic replication of vaccinia virus
  • Dalla Rosa I, Way M
  • doi: 10.1101/2025.02.05.636656

• Drosophila AHR limits tumor growth and stem cell proliferation in the intestine
  • Tsai M, Sun J, Alexandre C, Shapiro M, Franchet A, Li Y, Gould AP, Vincent J-P, Stockinger B, Diny NL
  • doi: 10.12688/wellcomeopenres.23515.1

• Functional specialisation of multisensory temporal integration in the mouse superior colliculus
  • Bianchini G, Razafindrahaba I, Moglie MJ, Konstantinou G, Cano-Ferrer X, Imbert A, Iacaruso MF
  • doi: 10.1101/2025.02.11.637674

• Rapid water permeation by aramid foldamer nanochannels with hydrophobic interiors
  • Farooq S, Malla JA, Nedyalkova M, Freire RVM, Mandal I, Crochet A, Salentinig S, Lattuada M, McTernan CT, Kilbinger AFM
  • doi: 10.26434/chemrxiv-2025-lz9xt

• Cross-species biomechanical determinants of shape diversity
  • Bailleul R, Cuny N, Khoromoskaia D, Basu S, Bergamini G, Cucurachi P, Rupp S, Guse A, Curantz C, Swinhoe N, Cleves P, Craggs J, Fujita S, Nakajima Y-I, Steenbergen PJ, Diz-Muñoz A, Salbreux G, Ikmi A
  • doi: 10.1101/2025.02.07.637025

• Cryptosporidium modifies intestinal microvilli through an exported virulence factor
  • Rodrigues E, Pallett MA, Straker LC, Mkandawire TT, Sala K, Collinson L, Sateriale A
  • doi: 10.1101/2025.02.25.639898

• 3D spatial transcriptomics reveals the molecular domain structure of the mouse olfactory bulb
  • Klimpert N, Kollo M, Brann DH, Tan C, Barry D, Ma Y, Schaefer AT, Fleischmann A
  • doi: 10.1101/2025.02.19.639192

• Insect wings arose with a genetic circuit that extends the useful range of a BMP morphogen
  • Huang A, Cocconi L, Nicholls-Mindlin B, Alexandre C, Salbreux G, Vincent J-P
  • doi: 10.1101/2025.02.07.637038

• Dissecting PADI6 function defines oocyte cytoplasmic lattices as regulatory hubs for fundamental cellular processes
  • Williams JPC, Auchynnikava T, McCarthy A, Ojarikre OA, Bertran MT, Weston AE, Leonce D, Olsen J, Niakan KK, Skehel M, Turner JMA, Walport LJ
  • doi: 10.1101/2025.02.21.639491

• Enhancing the efficiency of oncolytic vaccinia virus for ovarian cancer treatment
  • Drymiotou S, Queval CJ, Tyson KE, Sheach LA, Postigo A, Dalla Rosa I, Howell M, McNeish IA, Way M
  • doi: 10.1101/2025.02.04.636413

• Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle
  • Zeisner TU, Auchynnikava T, Nurse P
  • doi: 10.1101/2025.02.21.639482

• Subunit specialisation in AAA+ proteins and substrate unfolding during transcription complex remodelling
  • Gao F, Ye F, Buck M, Zhang X
  • doi: 10.1101/2025.02.15.638424