Features April 2025

• From cytokines to tuberculosis and back: My journey to understanding the immune response to infection
  • O'Garra, A
  • Annual Review of Immunology
  • doi: 10.1146/annurev-immunol-010824-041601 

Reviews April 2025

• Genetics and unexplained infant death: genomics in the courtroom
  • Arsov T, Vinuesa CG
  • Paediatria Croatica
  • doi: 10.13112/pc.1054
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• The role of extracellular matrix viscoelasticity in development and disease.
  • Courbot O, Elosegui-Artola A
  • npj Biological Physics and Mechanics
  • doi: 10.1038/s44341-025-00014-6
  • PDF

• Misinterpretation and misapplication of biomarkers in inflammatory bowel disease: how do we avoid this?
  • Varley RB, Lee JC
  • Expert Review of Gastroenterology and Hepatology
  • doi: 10.1080/17474124.2025.2482980
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• PEPSeek-mediated identification of novel epitopes from viral and bacterial pathogens and the impact on host cell immunopeptidomes.
  • Cormican JA, Medfai L, Wawrzyniuk M, Pašen M, Afrache H, Fourny C, Khan S, Gneiße P, Soh WT, Timelli A, Nolfi E, Pannekoek Y, Cope A, Urlaub H, Sijts AJAM, Mishto M, Liepe J
  • Molecular & Cellular Proteomics
  • doi: 10.1016/j.mcpro.2025.100937
  • PDF

• Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 in the assessment of vaccination and therapeutics.
  • Dowgier G, Hobbs A, Greenwood D, Shawe-Taylor M, Stevenson-Leggett P, Bazire J, Penn R, Harvey R, Crick COVID serology pipeline, Legacy Investigators, Libri V, Kassiotis G, Gamblin S, Lewis NS, Williams B, Swanton C, Gandhi S, Bauer DLV, Carr EJ, Wall EC, Wu MY
  • Vaccine
  • doi: 10.1016/j.vaccine.2025.126960
  • PDF

• Astrocytic RNA editing regulates the host immune response to alpha-synuclein.
  • D'Sa K, Choi ML, Wagen AZ, Setó-Salvia N, Kopach O, Evans JR, Rodrigues M, Lopez-Garcia P, Lachica J, Clarke BE, Singh J, Ghareeb A, Bayne J, Grant-Peters M, Garcia-Ruiz S, Chen Z, Rodriques S, Athauda D, Gustavsson EK, Gagliano Taliun SA, Toomey C, Reynolds RH, Young G, Strohbuecker S, Warner T, Rusakov DA, Patani R, Bryant C, Klenerman DA, Gandhi S, Ryten M
  • Science Advances
  • doi: 10.1126/sciadv.adp8504
  • PDF

• Identification of RING E3 pseudoligases in the TRIM protein family.
  • Dudley-Fraser J, Esposito D, McPhie KA, Morley-Williams C, Auchynnikava T, Rittinger K
  • Nature Communications
  • doi: 10.1038/s41467-025-58807-1
  • PDF

• Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multisite polarity substrate Lgl.
  • Earl CP, Cobbaut M, Barros-Carvalho A, Ivanova ME, Briggs DC, Morais-de-Sá E, Parker PJ, McDonald NQ
  • Nature Structural & Molecular Biology
  • doi: 10.1038/s41594-024-01425-0
  • PDF

• Caspase cleavage of influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production.
  • Figueras-Novoa C, Akutsu M, Murata D, Weston A, Jiang M, Montaner B, Dubois C, Shenoy A, Beale R
  • EMBO Reports
  • doi: 10.1038/s44319-025-00388-7
  • PDF

• Subunit specialization in AAA+ proteins and substrate unfolding during transcription complex remodeling.
  • Gao F, Ye F, Buck M, Zhang X
  • Proceedings of the National Academy of Sciences of the United States of America
  • doi: 10.1073/pnas.2425868122
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• Impact of metformin on HBV replication: No evidence of suppression in vitro.
  • Hawkins C, Waddilove E, Matthews PC, Delphin M
  • Journal of Clinical Virology
  • doi: 10.1016/j.jcv.2025.105781
  • PDF

• High-throughput screening of human genetic variants by pooled prime editing.
  • Herger M, Kajba CM, Buckley M, Cunha A, Strom M, Findlay GM
  • Cell Genomics
  • doi: 10.1016/j.xgen.2025.100814
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• Methodological considerations on how to identify human hematopoietic stem cells.
  • Hinchly T, Bonnet D, Anjos-Afonso F
  • Experimental Hematology
  • doi: 10.1016/j.exphem.2025.104729
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• Becker naevi are associated with neurologic abnormalities.
  • Lopez-Balboa P, Knöpfel N, Ramwani M, Muwanga-Nanyonjo N, O'Neill C, Lomas D, Cullup T, Polubothu S, Kinsler VA
  • Journal of the American Academy of Dermatology
  • doi: 10.1016/j.jaad.2024.09.085
  • PDF

• Cardiometabolic biomarkers and systemic inflammation in US adolescents and young adults with latent tuberculosis infection: a population-based cohort study
  • Magodoro IM, Ntusi NAB, Jao J, Zar HJ, Claggett BL, Siedner MJ, Wilkinson KA, Wilkinson RJ
  • Open Forum Infectious Diseases
  • doi: 10.1093/ofid/ofaf194
  • PDF

• Tumor-infiltrating clonal hematopoiesis.
  • Pich O, Bernard E, Zagorulya M, Rowan A, Pospori C, Slama R, Huerga Encabo H, O'Sullivan J, Papazoglou D, Anastasiou P, Iliakis CS, Clark S-A, Dijkstra KK, Barbè V, Bailey C, Stonestrom AJ, Enfield KSS, Green M, Brierley CK, Magness A, Pearce DR, Hynds RE, Zaidi R, Rane JK, Álvarez-Prado ÁF, Thol K, Scott R, Bola SK, Hoxha E, Harris SK, Peggs KS, Quezada SA, Hackshaw A, Zaccaria S, Joyce JA, Malanchi I, Berger MF, Jamal-Hanjani M, Wack A, Downward J, Grey W, Lo Celso C, Grönroos E, Rudin CM, Mead AJ, Bonnet D, Papaemmanuil E, Swanton C
  • New England Journal of Medicine
  • doi: 10.1056/NEJMoa2413361
  • PDF

• Horizontal acquisition of prokaryotic hopanoid biosynthesis reorganizes membrane physiology driving lifestyle innovation in a eukaryote.
  • Rao BD, Gomez-Gil E, Peter M, Balogh G, Nunes V, MacRae JI, Chen Q, Rosenthal PB, Oliferenko S
  • Nature Communications
  • doi: 10.1038/s41467-025-58515-w
  • PDF

• Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction.
  • Salcedo A, Tarabichi M, Buchanan A, Espiritu SMG, Zhang H, Zhu K, Ou Yang T-H, Leshchiner I, Anastassiou D, Guan Y, Jang GH, Mootor MFE, Haase K, Deshwar AG, Zou W, Umar I, Dentro S, Wintersinger JA, Chiotti K, Demeulemeester J, Jolly C, Sycza L, Ko M, PCAWG Evolution and Heterogeneity Working Group, SMC-Het Participants, Wedge DC, Morris QD, Ellrott K, Van Loo P, Boutros PC
  • Nature Biotechnology
  • doi: 10.1038/s41587-024-02250-y
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• NHS-Galleri trial: Enriched enrolment approaches and sociodemographic characteristics of enrolled participants
  • Swanton C, Bachtiar V, Mathews C, Brentnall AR, Lowenhoff I, Waller J, Bomb M, McPhail S, Pinches H, Smittenaar R, Hiom S, Neal RD, Sasieni P
  • Clinical Trials
  • doi: 10.1177/17407745241302477
  • PDF

• Evidence of substrate control of Cdk phosphorylation during the budding yeast cell cycle.
  • Takacs L, Gerontogianni L, Quililan K, Flynn H, Uhlmann F
  • Cell Reports
  • doi: 10.1016/j.celrep.2025.115534
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• GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies.
  • Torelli F, Butterworth S, Lockyer E, Matias AN, Hildebrandt F, Song O-R, Pearson-Farr J, Treeck M
  • Nature Communications
  • doi: 10.1038/s41467-025-58876-2
  • PDF

• Drosophila AHR limits tumor growth and stem cell proliferation in the intestine
  • Tsai M, Sun J, Alexandre C, Shapiro M, Franchet A, Li Y, Gould AP, Vincent J-P, Stockinger B, Diny NL
  • Wellcome Open Research
  • doi: 10.12688/wellcomeopenres.23515.3
  • PDF

• Systematic genetic perturbation reveals principles underpinning robustness of the epigenetic regulatory network.
  • Wilson TS, Noberini R, Moysidou E, Ojukwu I, Milan M, Jiang M, Kelly G, Howell M, Bonaldi T, Scaffidi P
  • Nucleic Acids Research
  • doi: 10.1093/nar/gkaf297
  • PDF

• Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN.
  • Youle RL, Lista MJ, Bouton C, Kunzelmann S, Wilson H, Cottee MA, Purkiss AG, Morris ER, Neil SJD, Taylor IA, Swanson CM
  • Journal of Biological Chemistry
  • doi: 10.1016/j.jbc.2025.108336
  • PDF

Preprints April 2025

• Chronobot: Deep learning guided time-resolved cryo-EMcaptures molecular choreography of RecA in homology search
  • Mäeots M-E, Tupin S, Esfahani MMN, Rodriguez Molina JB, Clapperton JA, Amin A, Imbert A, Enchev RI
  • doi: 10.1101/2025.04.21.649820

• Saturation genome editing of RNU4-2 reveals distinct dominant and recessive neurodevelopmental disorders
  • De Jonghe J, Kim HC, Adedeji A, Leitão E, Dawes R, Chen Y, Blakes AJM, Simons C, Rius R, Alvi JR, Amblard F, Austin-Tse C, Baer S, Balton EV, Blanc P, Calame DG, Coutton C, Cunningham CA, Dargie N, Dipple KM, Du H, El Chehadeh S, Glass I, Gleeson JG, Grunewald O, Gueguen P, Harbuz R, Jacquemont M-L, Leventer RJ, Marijon P, Messaoud O, Sultan T, Thauvin C, Vincent-Delorme C, Yilmaz Gulec E, Thevenon J, Mendez R, MacArthur DG, Depienne C, Nava C, Whiffin N, Findlay GM
  • doi: 10.1101/2025.04.08.25325442

• VP-CLEM-Kit: An accessible pipeline for visual proteomics using super resolution volume correlative light and electron microscopy (SR-vCLEM)
  • Lumkwana D, Lightley J, Vesga AG, de Folter J, Domart M-C, Maclachlan C, Kumar S, Evans J, Peddie C, Burrell A, Yoshimura A, Mangali A, Vahrjmeijer N, Bhaga M, Smit C, Titze B, Horrocks M, Straker LC, Garcia E, Jones M, Mclean A, Roufosse C, Loos B, Gandhi S, Strange A, Henriques R, French P, Collinson L
  • doi: 10.1101/2025.04.08.647770

• An intercellular metabolic relay for brain sparing in Drosophila
  • Franchet A, Jin Y, Newell CL, Girard V, Manière G, Grosjean Y, Barrington C, MacRae JI, Gilmore IS, Gould AP
  • doi: 10.1101/2025.04.02.645514

• A subset of Haematopoietic Stem Cells resists Plasmodium infection-induced stress by uncoupling interferon sensing and metabolic activation
  • Georgiou C, Liu Q, Gonzalez-Anton S, Bruno F, Birch F, Kinston SJ, Chabra S, Wilson NK, Pospori C, Blagborough AM, Göttgens B, Luis TC, Lo Celso C
  • doi: 10.1101/2025.04.09.647965

• Liver, cardiovascular and metabolic factors as predictors of all-cause mortality in a rural Ugandan Cohort.
  • Campbell C, Mugisha J, Kimono B, Waddilove E, Makanga R, Wang T, Muzaale FN, Matthews PC, Newton R
  • doi: 10.1101/2025.04.03.25325170

• Eligibility for hepatitis B virus (HBV) treatment and prevalence of drug resistance in a Ugandan population cohort.
  • Lumley SF, Kimono B, Mugisha J, Makanga R, Mbonye MK, Ojambo K, Waddilove E, Kent C, Ssengendo B, Ndungutse R, McNaughton AL, Nambaziira F, Seeley J, Quick J, Ocama P, Newton R, Matthews PC
  • doi: 10.1101/2025.04.06.25325341

• Do data management policies become more open over time?
  • Montague-Hellen B
  • doi: 10.31235/osf.io/gd4hp_v2