Features October 2024

• Holding your nerve in academia whilst managing multiple sclerosis
  • Bismillah A, Fielden SDP
  • Nature Reviews Chemistry
  • doi: 10.1038/s41570-024-00661-8
  • for a PDF of this article please contact kathy.weston@crick.ac.uk

Papers October 2024

• The history of chromosomal instability in genome-doubled tumors.
  • Baker TM, Lai S, Lynch AR, Lesluyes T, Yan H, Ogilvie HA, Verfaillie A, Dentro S, Bowes AL, Pillay N, Flanagan AM, Swanton C, Spellman PT, Tarabichi M, Van Loo P
  • Cancer Discovery
  • doi: 10.1158/2159-8290.CD-23-1249
  • PDF

• An extrinsic motor directs chromatin loop formation by cohesin.
  • Guérin TM, Barrington C, Pobegalov G, Molodtsov MI, Uhlmann F
  • The EMBO Journal
  • doi: 10.1038/s44318-024-00202-5
  • PDF

• Cancer immunotherapy by γδ T cells.
  • Hayday A, Dechanet-Merville J, Rossjohn J, Silva-Santos B
  • Science
  • doi: 10.1126/science.abq7248
  • No PDF available in repository

• A bioorthogonal precision tool for human N-acetylglucosaminyltransferase V.
  • Liu Y, Bineva-Todd G, Meek RW, Mazo L, Piniello B, Moroz O, Burnap SA, Begum N, Ohara A, Roustan C, Tomita S, Kjaer S, Polizzi K, Struwe WB, Rovira C, Davies GJ, Schumann B
  • Journal of the American Chemical Society
  • doi: 10.1021/jacs.4c05955
  • PDF

• Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site-deficient Ascl1.
  • Marichal N, Péron S, Beltrán Arranz A, Galante C, Franco Scarante F, Wiffen R, Schuurmans C, Karow M, Gascón S, Berninger B
  • Science Advances
  • doi: 10.1126/sciadv.adl5935
  • PDF

• Understanding developmental system drift.
  • McColgan Á, DiFrisco J
  • Development
  • doi: 10.1242/dev.203054
  • PDF

• Refractory autoimmune thrombocytopenia in an infant with a de novo TLR7 gain-of-function variant.
  • Menon S, Maurice D, Robinson LA, Milner J, Pascual V, Vinuesa CG, Kaicker S
  • Journal of Clinical Immunology
  • doi: 10.1007/s10875-024-01824-4

• Proteasome isoforms in human thymi and mouse models.
  • Mishto M, Takala I, Bonfanti P, Liepe J
  • Immunology Letters
  • doi: 10.1016/j.imlet.2024.106899
  • PDF

• Opportunities and challenges for T cell-based influenza vaccines.
  • Mosmann TR, McMichael AJ, LeVert A, McCauley JW, Almond JW
  • Nature Reviews Immunology
  • doi: 10.1038/s41577-024-01030-8

• A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation.
  • Ocasio CA, Baggelaar MP, Sipthorp J, Losada de la Lastra A, Tavares M, Volarić J, Soudy C, Storck EM, Houghton JW, Palma-Duran SA, MacRae JI, Tomić G, Carr L, Downward J, Eggert US, Tate EW
  • Nature Biotechnology
  • doi: 10.1038/s41587-023-02030-0
  • PDF

• Advanced three-dimensional X-ray imaging unravels structural development of the human thymus compartments.
  • Savvidis S, Ragazzini R, de Rafael VC, Hutchinson JC, Massimi L, Vittoria FA, Campinoti S, Partridge T, Ogunbiyi OK, Atzeni A, Sebire NJ, De Coppi P, Mittone A, Bravin A, Bonfanti P, Olivo A
  • Communications Medicine
  • doi: 10.1038/s43856-024-00623-7
  • PDF

• In vitro analysis suggests that SARS-CoV-2 infection differentially modulates cancer-like phenotypes and cytokine expression in colorectal and prostate cancer cells.
  • Serwaa A, Oyawoye F, Owusu IA, Dosoo D, Manu AA, Sobo AK, Fosu K, Olwal CO, Quashie PK, Aikins AR
  • Scientific Reports
  • doi: 10.1038/s41598-024-75718-1
  • PDF

• The influence of AHR on immune and tissue biology.
  • Stockinger B, Diaz OE, Wincent E
  • EMBO Molecular Medicine
  • doi: 10.1038/s44321-024-00135-w
  • PDF

• Creation of de novo cryptic splicing for ALS and FTD precision medicine
  • Wilkins OG, Chien MZYJ, Wlaschin JJ, Barattucci S, Harley P, Mattedi F, Mehta PR, Pisliakova M, Ryadnov E, Keuss MJ, Thompson D, Digby H, Knez L, Simkin RL, Diaz JA, Zanovello M, Brown A-L, Darbey A, Karda R, Fisher EMC, Cunningham TJ, Le Pichon CE, Ule J
  • Science
  • doi: 10.1126/science.adk2539
  • no PDF available - see Crick news article

• Expanding the repertoire of GalNAc analogues for cell-specific bioorthogonal tagging of glycoproteins.
  • Zafar A, Sridhar S, Bineva-Todd G, Cioce A, Abdulla N, Chang V, Malaker SA, Hewings DS, Schumann B
  • RSC Chemical Biology
  • doi: 10.1039/d4cb00093e
  • PDF

Preprints October 2024

• Identification of a specialized lipid barrier for Drosophila metamorphosis
  • Lampe L, Newell CL, Wang B-J, Makki R, Alexandre C, Gilmore IS, Zhao L, Gould AP
  • doi: 10.1101/2024.10.11.617838

• Deep learning assisted proton pure shift NMR spectroscopy
  • Kakita VMR, Hansen DF
  • doi: 10.26434/chemrxiv-2024-ln3pk

• Integrative analysis of higher-order transcriptome organisation and RNA condensation principles
  • Klobučar T, Novljan J, Iosub IA, Kokot B, Urbančič I, Jones DM, Chakrabarti AM, Luscombe NM, Ule J, Modic M
  • doi: 10.1101/2024.10.14.618182

• Imaging of live bacterial whole-cell biosensors illuminates spatial sialic acid availability within the inflamed mammalian gut.
  • Carreño D, Robinson CM, Jackson R, Li P, Nunes V, Palma-Duran SA, Nye E, MacRae JI, Riglar DT
  • doi: 10.1101/2024.10.23.619804

• Identification of RING E3 pseudoligases in the TRIM protein family
  • Dudley-Fraser J, Esposito D, McPhie K, Morley-Williams C, Auchynnikava T, Rittinger K
  • doi: 10.1101/2024.10.15.614675

• Growth compensation upon changes in tissue size in the Drosophila abdomen
  • Ferreira A, Cairoli A, Mangione F, Holder MV, Ainslie A, Aerne BL, Salbreux G, Tapon N
  • doi: 10.1101/2024.10.02.616326

• Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma
  • Noorani I, Haughey M, Luebeck J, Rowan A, Grönroos E, Terenzi F, Wong IT-L, Kittel J, Bailey C, Weeden C, Bell D, Joo E, Barbe V, Jones MG, Nye E, Green M, Meader L, Norton EJ, Fabian M, Kanu N, Jamal-Hanjani M, Santarius T, Nicoll J, Boche D, Chang HY, Bafna V, Huang W, Mischel PS, Swanton C, Werner B
  • doi: 10.1101/2024.10.22.619657

• Meru co-ordinates spindle orientation with cell polarity and cell cycle progression
  • McLellan MM, Aerne BL, Banerjee Dhoul JJ, Tapon N
  • doi: 10.1101/2024.10.01.616065

• Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens
  • Torelli F, da Fonseca DM, Butterworth S, Young JC, Treeck M
  • doi: 10.7554/elife.102592.1