Papers August 2024

• A co-ordinated transcriptional programme in the maternal liver supplies long chain polyunsaturated fatty acids to the conceptus using phospholipids
  • Amarsi R, Furse S, Cleaton MAM, Maurel S, Mitchell AL, Ferguson-Smith AC, Cenac N, Williamson C, Koulman A, Charalambous M
  • Nature Communications
  • doi: 10.1038/s41467-024-51089-z
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• Loss of ARID3A perturbs intestinal epithelial proliferation-differentiation ratio and regeneration.
  • Angelis N, Baulies A, Hubl F, Kucharska A, Kelly G, Llorian M, Boeing S, Li VSW
  • Journal of Experimental Medicine
  • doi: 10.1084/jem.20232279
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• Optimized PAR-2 RING dimerization mediates cooperative and selective membrane binding for robust cell polarity.
  • Bland T, Hirani N, Briggs DC, Rossetto R, Ng K, Taylor IA, McDonald NQ, Zwicker D, Goehring NW
  • The EMBO Journal
  • doi: 10.1038/s44318-024-00123-3
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• Why do patients with cancer die?
  • Boire A, Burke K, Cox TR, Guise T, Jamal-Hanjani M, Janowitz T, Kaplan R, Lee R, Swanton C, Vander Heiden MG, Sahai E
  • Nature Reviews Cancer
  • doi: 10.1038/s41568-024-00708-4
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• Physiologic medium renders human iPSC-derived macrophages permissive for M. tuberculosis by rewiring organelle function and metabolism.
  • Bussi C, Lai R, Athanasiadi N, Gutierrez MG
  • mBio
  • doi: 10.1128/mbio.00353-24
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• Integrated cryoEM structure of a spumaretrovirus reveals cross-kingdom evolutionary relationships and the molecular basis for assembly and virus entry.
  • Calcraft T, Stanke-Scheffler N, Nans A, Lindemann D, Taylor IA, Rosenthal PB
  • Cell
  • doi: 10.1016/j.cell.2024.06.017
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• CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes.
  • Cao L, Huang S, Basant A, Mladenov M, Way M
  • EMBO Reports
  • doi: 10.1038/s44319-024-00201-x
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• Peer support for people living with hepatitis B virus-A foundation for treatment expansion.
  • Downs LO, Kabagambe K, Williams S, Waddilove E, Delphin M, Lumley SF, Ndungutse R, Kimono B, Newton R, Ko J, Martyn E, Carter J, Kemper A, Monteiro F, O'Regan S, Surey J, Sultan B, Story A, MacDonald D, Tu T, Seeley J, Dusheiko G, Maponga T, Andersson MI, Spearman CW, Tucker JD, Cohen C, Wang S, Adda D, Freeland C, Halford R, Jack K, Ghosh I, Elsharkawy AM, Matthews PC, Flanagan S
  • Journal of Viral Hepatitis
  • doi: 10.1111/jvh.13952
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• Conjugation of ATG8s to single membranes at a glance.
  • Figueras-Novoa C, Timimi L, Marcassa E, Ulferts R, Beale R
  • Journal of Cell Science
  • doi: 10.1242/jcs.261031
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• Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
  • Henrikus SS, Gross MH, Willhoft O, Pühringer T, Lewis JS, McClure AW, Greiwe JF, Palm G, Nans A, Diffley JFX, Costa A
  • Nature Structural and Molecular Biology
  • doi: 10.1038/s41594-024-01280-z
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• Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis.
  • Khan MZ, Hunt DM, Singha B, Kapoor Y, Singh NK, Prasad DVS, Dharmarajan S, Sowpati DT, de Carvalho LPS, Nandicoori VK
  • Elife
  • doi: 10.7554/eLife.91970
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• Multi-signal regulation of the GSK-3β homolog Rim11 controls meiosis entry in budding yeast.
  • Kociemba J, Jørgensen ACS, Tadić N, Harris A, Sideri T, Chan WY, Ibrahim F, Ünal E, Skehel M, Shahrezaei V, Argüello-Miranda O, van Werven FJ
  • The EMBO Journal
  • doi: 10.1038/s44318-024-00149-7
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• Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition.
  • Krammer T, Stuart HT, Gromberg E, Ishihara K, Cislo D, Melchionda M, Becerril Perez F, Wang J, Costantini E, Lehr S, Arbanas L, Hörmann A, Neumüller RA, Elvassore N, Siggia E, Briscoe J, Kicheva A, Tanaka EM
  • Developmental Cell
  • doi: 10.1016/j.devcel.2024.04.021
  • No PDF

• Mucosal associated invariant T cells: Powerhouses of the lung.
  • López-Rodríguez JC, Barral P
  • Immunology Letters
  • doi: 10.1016/j.imlet.2024.106910
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• Single molecule dynamics in a virtual cell combining a 3-dimensional matrix model with random walks
  • Mashanov GI, Molloy JE
  • Scientific Reports
  • doi: 10.1038/s41598-024-70925-2
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• Lysosomes drive the piecemeal removal of mitochondrial inner membrane.
  • Prashar A, Bussi C, Fearns A, Capurro MI, Gao X, Sesaki H, Gutierrez MG, Jones NL
  • Nature
  • doi: 10.1038/s41586-024-07835-w
  • No PDF

• Cellular immune response to SARS-CoV-2 and clinical presentation in individuals exposed to endemic malaria.
  • Tapela K, Prah DA, Tetteh B, Nuokpem F, Dosoo D, Coker A, Kumi-Ansah F, Amoako E, Assah KO, Kilba C, Nyakoe N, Quansah D, Languon S, Anyigba CA, Ansah F, Agyeman S, Owusu IA, Schneider K, Ampofo WK, Mutungi JK, Amegatcher G, Aniweh Y, Awandare GA, Quashie PK, Bediako Y
  • Cell Reports
  • doi: 10.1016/j.celrep.2024.114533
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• The V-ATPase/ATG16L1 axis is controlled by the V1H subunit.
  • Timimi L, Wrobel AG, Chiduza GN, Maslen SL, Torres-Méndez A, Montaner B, Davis C, Minckley T, Hole KL, Serio A, Devine MJ, Skehel JM, Rubinstein JL, Schreiber A, Beale R
  • Molecular Cell
  • doi: 10.1016/j.molcel.2024.07.003
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• The AHR repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils.
  • Weighardt H, Shapiro M, Mayer M, Förster I, Stockinger B, Diny NL
  • Journal of Leukocyte Biology
  • doi: 10.1093/jleuko/qiae105
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• Peptidic boronic acid Plasmodium falciparum SUB1 inhibitors with improved selectivity over human proteasome.
  • Withers-Martinez C, Lidumniece E, Hackett F, Collins CR, Taha Z, Blackman MJ, Jirgensons A
  • Journal of Medicinal Chemistry
  • doi: 10.1021/acs.jmedchem.4c01005

Preprints August 2024

• GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome
  • Roeselová A, Maslen SL, He JZ, Jurkeviciute G, Skehel MJ, Enchev R, Balchin D
  • doi: 10.1101/2024.08.12.607569

• Protein degradation shapes developmental tempo in mouse and human neural progenitors
  • Nakanoh S, Stamataki D, Garcia-Perez L, Azzi C, Carr HL, Pokhilko A, Yu L, Howell S, Skehel M, Oxley D, Andrews S, Briscoe J, Rayon T
  • doi: 10.1101/2024.08.01.604391

• Results of the protein engineering tournament: An open science benchmark for protein modeling and design
  • Armer C, Kane H, Cortade DL, Redestig H, Estell DA, Yusuf A, Rollins N, Spinner H, Marks D, Brunette TJ, Kelly PJ, DeBenedictis E
  • doi: 10.1101/2024.08.12.606135

• Refining gene delivery to skeletal muscle with a dual-strategy approach of muscle-tropic AAV capsids and muscle-specific promoters
  • Darbey A, Jin W, Greensmith L, Sleigh JN, Counsell J, Fratta P
  • doi: 10.1101/2024.08.02.605568

• Horizontal gene transfer-initiated reorganization of lipid metabolism drives lifestyle innovation in a eukaryote
  • Rao BD, Gomez Gil E, Peter M, Balogh G, Nunes V, MacRae JI, Chen Q, Rosenthal P, Oliferenko S
  • doi: 10.1101/2024.08.21.608818

• A biologically inspired attention model for neural signal analysis
  • Skatchkovsky N, Glazman N, Sadeh S, Iacaruso F
  • doi: 10.1101/2024.08.13.607787

• Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens
  • Torelli F, da Fonseca DM, Butterworth S, Young JC, Treeck M
  • doi: 10.1101/2024.08.23.609334

• Discovering covalent cyclic peptide inhibitors of peptidyl arginine deiminase 4 (PADI4) using mRNA-display with a genetically encoded electrophilic warhead
  • Mathiesen IR, Calder EDD, Kunzelmann S, Walport LJ
  • doi: 10.26434/chemrxiv-2024-w8nbl