Interviews and profiles July 2024

• An interview with Jean-Paul Vincent.
  • Vincent JP
  • Development 151: dev203105.
  • doi: 10.1242/dev.203105
  • PDF

• The geneticist who uses science to free parents wrongly convicted of killing their children
  • Plackett B
  • Nature
  • doi: 10.1038/d41586-024-02324-6

Papers July 2024

• Implementing circulating tumor DNA as a prognostic biomarker in resectable non-small cell lung cancer.
  • Abbosh C, Hodgson D, Doherty GJ, Gale D, Black JRM, Horn L, Reis-Filho JS, Swanton C
  • Trends in Cancer
  • doi: 10.1016/j.trecan.2024.04.004
  • PDF

• Long-term potentiation: 50 years on: past, present and future
  • Abraham WC, Bliss TVP, Collingridge GL, Morris RGM
  • Philosophical Transactions of the Royal Society B: Biological Sciences
  • doi: 10.1098/rstb.2023.0218
  • PDF

• CRISPR-Cas9 screening identifies KRAS-induced COX2 as a driver of immunotherapy resistance in lung cancer.
  • Boumelha J, de Castro A, Bah N, Cha H, de Carné Trécesson S, Rana S, Tomaschko M, Anastasiou P, Mugarza E, Moore C, Goldstone R, East P, Litchfield K, Lee S-H, Molina-Arcas M, Downward J
  • Cancer Research
  • doi: 10.1158/0008-5472.CAN-23-2627
  • PDF

• Saturation genome editing maps the functional spectrum of pathogenic VHL alleles.
  • Buckley M, Terwagne C, Ganner A, Cubitt L, Brewer R, Kim D-K, Kajba CM, Forrester N, Dace P, De Jonghe J, Shepherd STC, Sawyer C, McEwen M, Diederichs S, Neumann-Haefelin E, Turajlic S, Ivakine EA, Findlay GM
  • Nature Genetics
  • doi: 10.1038/s41588-024-01800-z
  • PDF

• Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma.
  • Culliford R, Lawrence SED, Mills C, Tippu Z, Chubb D, Cornish AJ, Browning L, Kinnersley B, Bentham R, Sud A, Pallikonda H, The Renal Cancer Genomics England Consortium, Frangou A, Gruber AJ, Litchfield K, Wedge D, Larkin J, Turajlic S, Houlston RS
  • Nature Communications
  • doi: 10.1038/s41467-024-49692-1
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• Optical projection tomography implemented for accessibility and low cost (OPTImAL).
  • Darling C, Kumar S, Alexandrov Y, de Faye J, Almagro Santiago J, Rýdlová A, Bugeon L, Dallman MJ, Behrens AJ, French PMW, Mcginty J
  • Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
  • doi: 10.1098/rsta.2023.0101
  • PDF

• Wireless monitoring of respiration with EEG reveals relationships between respiration, behaviour and brain activity in freely moving mice.
  • Dasgupta D, Schneider-Luftman D, Schaefer AT, Harris JJ
  • Journal of Neurophysiology
  • doi: 10.1152/jn.00330.2023
  • PDF

• Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution.
  • Dietzen M, Zhai H, Lucas O, Pich O, Barrington C, Lu W-T, Ward S, Guo Y, Hynds RE, Zaccaria S, Swanton C, McGranahan N, Kanu N
  • Nature Communications
  • doi: 10.1038/s41467-024-50107-4
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• Tumor promoters and opportunities for molecular cancer prevention.
  • Hill W, Weeden CE, Swanton C
  • Cancer Discovery
  • doi: 10.1158/2159-8290.CD-24-0128
  • PDF

• APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease.
  • Hung C, Fertan E, Livesey FJ, Klenerman D, Patani R
  • Brain
  • doi: 10.1093/brain/awae092
  • PDF

• The impact of IDR phosphorylation on the RNA binding profiles of proteins.
  • Modic M, Adamek M, Ule J
  • Trends in Genetics
  • doi: 10.1016/j.tig.2024.04.004
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• Structural anisotropy results in mechano-directional transport of proteins across nuclear pores
  • Panagaki F, Tapia-Rojo R, Zhu T, Milmoe N, Paracuellos P, Board S, Mora M, Walker J, Rostkova E, Stannard A, Infante E, Garcia-Manyes S
  • Nature Physics
  • doi: 10.1038/s41567-024-02438-8
  • PDF

• Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery.
  • Parkhill SL, Johnson EO
  • Biochemical Journal
  • doi: 10.1042/BCJ20220062
  • PDF

• Virus-shaped mesoporous silica nanostars to improve the transport of drugs across the blood-brain barrier.
  • Pinna A, Ragaisyte I, Morton W, Angioletti-Uberti S, Proust A, D'Antuono R, Luk CH, Gutierrez MG, Cerrone M, Wilkinson KA, Mohammed AA, McGilvery CM, Suárez-Bonnet A, Zimmerman M, Gengenbacher M, Wilkinson RJ, Porter AE
  • ACS Applied Materials and Interfaces
  • doi: 10.1021/acsami.4c06726
  • PDF

• Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial.
  • Porter JC, Inshaw J, Solis VJ, Denneny E, Evans R, Temkin MI, De Vasconcelos N, Valle Aramburu I, Hoving D, Basire D, Crissell T, Guinto J, Webb A, Esmail H, Johnston V, Last A, Rampling T, Lippert L, Helbig ET, Kurth F, Williams B, Flynn A, Lukey PT, Birault V, Papayannopoulos V
  • Elife
  • doi: 10.7554/eLife.87030
  • PDF

• Naturally sterile Mus spretus hybrids are suitable for the generation of pseudopregnant embryo transfer recipients.
  • Preece C, Biggs D, Grencis E, Jackson MS, Allen S, Fray M, Adamson A, Davies B
  • Lab Animal
  • doi: 10.1038/s41684-024-01393-4
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• Mechanism of chaperone coordination during cotranslational protein folding in bacteria.
  • Roeselová A, Maslen SL, Shivakumaraswamy S, Pellowe GA, Howell S, Joshi D, Redmond J, Kjær S, Skehel JM, Balchin D
  • Molecular Cell
  • doi: 10.1016/j.molcel.2024.06.002
  • PDF

• Retrospective analysis of hospital electronic health records reveals unseen cases of acute hepatitis with unknown aetiology in adults in Oxfordshire.
  • Tan CCS, Kelly G, Cregan J, Wilson JD, James T, Chand M, Hopkins S, Swets M, Baillie JK, Jeffery K, Walker AS, Eyre DW, Stoesser N, Matthews PC
  • BMC Public Health
  • doi: 10.1186/s12889-024-19292-1
  • PDF

Preprints July 2024

• ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair
  • De Tito S, Almacellas E, Yu DD, Zhang W, Millard E, Hervás JH, Pellegrino E, Panagi I, Fodge D, Thurston TLM, Gutierrez M, Tooze SA
  • doi: 10.1101/2024.07.23.604321

• Hepatitis B core related antigen - Does it meet our expectations? Evidence from cohorts in the United Kingdom and South Africa
  • Downs LO, Delphin M, van Schalwyk M, Hugo S, Gabriel S, Lumley S, Waddilove E, Wang T, De Lara C, Babbs A, Wareing S, Fengou P, Andersson MI, Glashoff R, Martin J, Ansari MA, Agarwal K, Dusheiko G, Taljaard J, Preiser W, Barnes E, Kelly G, Carey I, Maponga T, Matthews PC
  • doi: 10.1101/2024.07.29.24311156

• Super-resolution imaging of proteins inside live mammalian cells with mLIVE-PAINT
  • Bhaskar H, Gidden Z, Virdi G, Kleinjan D-J, Rosser SJ, Gandhi S, Regan L, Horrocks MH
  • doi: 10.1101/2024.07.22.604574

• Structures of TGF-β with betaglycan and the signaling receptors reveal the mechanism whereby betaglycan potentiates receptor complex assembly and signaling
  • Wieteska Ł, Taylor AB, Punch E, Coleman JA, Conway IO, Lin Y-F, Byeon C-H, Hinck CS, Krzysiak T, Ishima R, López-Casillas F, Cherepanov P, Bernard DJ, Hill CS, Hinck AP
  • doi: 10.1101/2024.07.19.604101

• Multiscale mechanics drive functional maturation of the vertebrate heart
  • Andrews TGR, Cornwall-Scoones J, Ramel M-C, Gupta K, Briscoe J, Priya R
  • doi: 10.1101/2024.07.24.604962

• ETV4 and ETV5 orchestrate FGF-mediated lineage specification and epiblast maturation during early mouse development
  • Simon CS, Garg V, Kuo Y-Y, Niakan KK, Hadjantonakis A-K
  • doi: 10.1101/2024.07.24.604964

• STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair
  • van den Heuvel D, Rodríguez-Martínez M, van der Meer PJ, Nieto Moreno N, Park J, Kim H-S, van Schie JJM, Wondergem AP, D'Souza A, Yakoub G, Herlihy AE, Kashyap K, Boissière T, Walker J, Mitter R, Apelt K, de Lint K, Kirdök I, Ljungman M, Wolthuis RMF, Cramer P, Schärer OD, Kokic G, Svejstrup J, Luijsterburg MS
  • doi: 10.1101/2024.07.22.604575

• Ancient Borrelia genomes document the evolutionary history of louse-borne relapsing fever
  • Swali P, Booth T, Tan CCS, McCabe J, Anastasiadou K, Barrington C, Borrini M, Bricking A, Buckberry J, Büster L, Carlin R, Gilardet A, Glocke I, Irish J, Kelly M, King M, Petchey F, Peto J, Silva M, Speidel L, Tait F, Teoaca A, Valoriani S, Williams M, Madgwick R, Mullan G, Wilson L, Cootes K, Armit I, Gutierrez MG, van Dorp L, Skoglund P
  • doi: 10.1101/2024.07.18.603748

• PP1 PNUTS binds the “restrictor” and dephosphorylates RNA pol II CTD Ser5 to stimulate transcription termination
  • Erickson B, Fedoryshchak R, Fong N, Sheridan R, Larson KY, Saviola AJ, Mouilleron S, Hansen KC, Treisman R, Bentley DL
  • doi: 10.1101/2024.07.12.603302

• Systematic identification of Y-chromosome gene functions in mouse spermatogenesis
  • Subrini J, Varsally W, Balaguer Balsells I, Bensberg M, Sioutas G, Ojarikre O, Maciulyte V, Gylemo B, Crawley K, Courtis K, de Rooij DG, Turner JMA
  • doi: 10.1101/2024.07.18.604063

• Branched actin networks in innate immune cells mediate host microbiota homeostasis
  • Vasconcellos LRC, Huang SCM, Suarez-Bonnet A, Priestnall S, Varsani-Brown S, Winder ML, Shah K, Kogata N, Stockinger B, Way M
  • doi: 10.1101/2024.07.18.604111

• Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin
  • Carver A, Yu T-Y, Yates LA, White T, Wang R, Lister K, Jasin M, Zhang X
  • doi: 10.1101/2024.07.16.603765

• Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics
  • Biggs GS, Cawood EE, Vuorinen A, McCarthy WJ, Wilders H, Riziotis IG, van der Zouwen AJ, Pettinger J, Nightingale L, Chen P, Powell AJ, House D, Boulton SJ, Skehel JM, Rittinger K, Bush JT
  • doi: 10.1101/2024.07.25.605137