Preprints May 2024

• Imaging of MAP kinase dynamics reveals endocytic regulation of pulsatile signalling and network re-wiring in response to targeted therapy in EGFR-mutant non-small cell lung cancer
  • Le Marois A, Bailey S, Hooper S, Kumar S, Sparks H, Alexandrov Y, Caswell D, Frӧhlich F, Schlegelmilch K, Valand K, Martin M, Narvaez A, Swanton C, Downward J, Dunsby C, French P, Sahai E
  • doi: 10.1101/2024.05.14.594112

• An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast
  • Libby ARG, Rito T, Radley A, Briscoe J
  • doi: 10.1101/2024.05.16.594506

• Marsupial single-cell transcriptomics provides an atlas of developmental heterochrony
  • Menchero S, Barrington C, Alanis-Lobato G, Varsally W, Niakan KK, Turner JMA
  • doi: 10.1101/2024.05.26.595746

• The role of metabolism in shaping enzyme structures over 400 million years of evolution
  • Lemke O, Heineike BM, Viknander S, Cohen N, Steenwyk JL, Spranger L, Li F, Agostini F, Lee CT, Aulakh SK, Nielsen J, Rokas A, Berman J, Zelezniak A, Gossmann TI, Ralser M
  • doi: 10.1101/2024.05.27.596037

• A bioorthogonal precision tool for human N-acetylglucosaminyltransferase V
  • Liu Y, Bineva-Todd G, Meek R, Mazo L, Piniello B, Moroz O, Begum N, Ohara A, Roustan C, Tomita S, Kjaer S, Polizzi K, Rovira C, Davies GJ, Schumann B
  • doi: 10.26434/chemrxiv-2024-856gt

• The CSF transcriptome in pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality
  • Guerra-Assunção JA, Chakravarty P, Pollara G, Venturini C, Mlozowa VS, Denis B, Nyirenda M, Lalloo DG, Noursadeghi M, Brown JS, Heyderman RS, Wall EC
  • doi: 10.1101/2024.05.24.592913

• p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis
  • Wittke CI, Cheung EC, Athineos D, Clements N, Butler L, Hughes M, Morrison V, Watt DM, Blyth K, Vousden KH, Humpton TJ
  • doi: 10.1101/2024.05.20.594983

Papers May 2024

• Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis
  • Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
  • Nature Communications
  • doi: 10.1038/s41467-024-48237-w
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• Increasing the diagnostic yield of childhood glaucoma cases recruited into the 100,000 Genomes Project.
  • Al-Saei O, Malka S, Owen N, Aliyev E, Vempalli FR, Ocieczek P, Al-Khathlan B, Genomics England Research Consortium, Fakhro K, Moosajee M
  • BMC Genomics
  • doi: 10.1186/s12864-024-10353-8
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• Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis.
  • Alvarez-Martinez M, Cox LS, Pearson CF, Branchett WJ, Chakravarty P, Wu X, Slawinski H, Al-Dibouni A, Samelis VA, Gabryšová L, Priestnall SL, Suárez-Bonnet A, Mikolajczak A, Briscoe J, Powrie F, O'Garra A
  • Nature Immunology
  • doi: 10.1038/s41590-024-01814-z
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• Cycling back to folate metabolism in cancer.
  • Lee Y, Vousden KH, Hennequart M
  • Nature Cancer
  • doi: 10.1038/s43018-024-00739-8
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• Mechanism of single-stranded DNA annealing by RAD52-RPA complex.
  • Liang C-C, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC
  • Nature
  • doi: 10.1038/s41586-024-07347-7
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• Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament.
  • Liu T, Cao L, Mladenov M, Jegou A, Way M, Moores CA
  • Nature Structural and Molecular Biology
  • doi: 10.1038/s41594-023-01205-2
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• Reconstructing developmental trajectories using latent dynamical systems and time-resolved transcriptomics
  • Maizels RJ, Snell DM, Briscoe J
  • Cell Systems
  • doi: 10.1016/j.cels.2024.04.004
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• Influence of donor-recipient sex on engraftment of normal and leukemia stem cells in xenotransplantation.
  • Mian SA, Ariza-McNaughton L, Anjos-Afonso F, Guring R, Jackson S, Kizilors A, Gribben J, Bonnet D
  • HemaSphere
  • doi: 10.1002/hem3.80
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• A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial.
  • Noor NM, Lee JC, Bond S, Dowling F, Brezina B, Patel KV, Ahmad T, Banim PJ, Berrill JW, Cooney R, De La Revilla Negro J, de Silva S, Din S, Durai D, Gordon JN, Irving PM, Johnson M, Kent AJ, Kok KB, Moran GW, Mowat C, Patel P, Probert CS, Raine T, Saich R
  • Lancet Gastroenterology and Hepatology
  • doi: 10.1016/S2468-1253(24)00034-7
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• The role of glial cells in amyotrophic lateral sclerosis.
  • Pandya VA, Patani R
  • International Review of Neurobiology
  • doi: 10.1016/bs.irn.2024.04.005
  • Full text

• Monogenic lupus: insights into disease pathogenesis and therapeutic opportunities.
  • Qin Y, Ma J, Vinuesa CG
  • Current Opinion in Rheumatology
  • doi: 10.1097/BOR.0000000000001008
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• Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis.
  • Tomić G, Sheridan C, Refermat AY, Baggelaar MP, Sipthorp J, Sudarshan B, Ocasio CA, Suárez-Bonnet A, Priestnall SL, Herbert E, Tate EW, Downward J
  • Cell Reports
  • doi: 10.1016/j.celrep.2024.114224
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• Metal-peptidic cages—Helical oligoprolines generate highly anisotrophic nanospaces with emergent isomer contro
  • Barber BE, Jamieson EMG, White, LEM, McTernan, CT
  • Chem
  • doi:  10.1016/j.chempr.2024.05.002
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• The sex of organ geometry
  • Blackie L, Gaspar P, Mosleh S, Lushchak O, Kong L, Jin Y, Zielinska AP, Cao B, Mineo A, Silva B, Ameku T, Lim SE, Mao Y, Prieto-Godino L, Schoborg T, Varela M, Mahadevan L, Miguel-Aliaga I
  • Nature
  • doi: 10.1038/s41586-024-07463-4
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