Preprints April 2024

• Caspase cleavage of Influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production
  • Figueras-Novoa C, Akutsu M, Murata D, Jiang M, Montaner B, Dubois C, Shenoy AR, Beale R
  • doi: 10.1101/2024.04.04.588074

• HIV-1 capsid rapidly induces long lived CPSF6 puncta in non-dividing cells but similar puncta already exist in uninfected T-cells
  • Guedán A, Burley M, Caroe ER, Bishop KN
  • doi: 10.1101/2024.03.29.587340

• HIV-1 Vpr causes separate cell cycle arrests in G2 and M that activate alternative DNA damage pathways
  • Hall R, Ahern LM, Yap MW, Tsai M-HC, Boucherit VC, Takaki T, Boulton SJ, Bishop KN
  • doi: 10.1101/2024.04.02.587683

• The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
  • Zhang I, Boezio GLM, Cornwall-Scoones J, Frith T, Jiang M, Howell M, Lovell-Badge R, Sagner A, Briscoe J, Delás MJ
  • doi: 10.1101/2024.04.17.589864

• Monolayer force generation and transmission is dictated by focal adhesion distribution
  • Davis JR, Solowiej-Wedderburn J, Vega SL, Burdick JA, Dunlop C, Tapon N
  • doi: 10.1101/2024.04.10.588783

• MCM double hexamer loading visualised with human proteins
  • Weissmann F, Greiwe JF, Pühringer T, Miller TCR, Diffley JFX, Costa A
  • doi: 10.1101/2024.04.10.588848

• Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses
  • Cole M, Anastasiou P, Lee C, Moore C, Mugarza E, Jones M, Valand K, Rana S, Colliver E, Angelova M, Enfield KSS, Magness A, Mullokandov A, Kelly G, de Gruijl TD, Molina-Arcas M, Swanton C, Downward J, van Maldegem F
  • doi: 10.1101/2024.04.11.588725

• High-throughput screening of human genetic variants by pooled prime editing
  • Herger M, Kajba CM, Buckley M, Cunha A, Strom M, Findlay GM
  • doi: 10.1101/2024.04.01.587366

• Characterising aromatic side chains in proteins through the synergistic development of NMR experiments and deep neural networks
  • Shukla VK, Karunanithy G, Vallurupalli P, Hansen DF
  • doi: 10.1101/2024.04.01.587635

• Riboseq-flow: A streamlined, reliable pipeline for ribosome profiling data analysis and quality control
  • Iosub IA, Wilkins OG, Ule J
  • doi: 10.12688/wellcomeopenres.21000.1

• Robust encoding of sub-sniff temporal information in the mouse olfactory bulb
  • Warner TPA, Tootoonian S, Schaefer AT
  • doi: 10.1101/2024.03.26.586830

• Accurate evaluation of live-virus microneutralization for SARS-CoV-2 variant JN.1
  • Dowgier G, Hobbs A, Greenwood D, Shawe-Taylor M, Stevenson-Leggett P, Bazire J, Penn R, Harvey R, Crick COVID serology pipeline, Legacy Investigators, Libri V, Kassiotis G, Gamblin S, Lewis NS, Williams B, Swanton C, Gandhi S, Bauer DLV, Carr EJ, Wall EC
  • doi: 10.1101/2024.04.17.589886

• Mutations in the IgG B cell receptor associated with class-switched B cell lymphomas
  • Wasim L, Chu SWT, Sale B, Pickard L, Léonard S, Zhang L, Tolarová H, Tean ZS, Engels N, Calado DP, Tarte K, Okosun J, Forconi F, Tolar P
  • doi: 10.1101/2024.04.12.585865

Papers April 2024

• Budding yeast as an ideal model for elucidating the role of N6 -methyladenosine in regulating gene expression.
  • Albihlal WS, Chan WY, van Werven FJ
  • Yeast
  • doi: 10.1002/yea.3925
  • PDF

• TOR regulates variability of protein synthesis rates.
  • Basier C, Nurse P
  • The EMBO Journal
  • doi: 10.1038/s44318-024-00075-8
  • PDF

• Increasing knockin efficiency in mouse zygotes by transient hypothermia.
  • Bouchareb A, Biggs D, Alghadban S, Preece C, Davies B
  • The CRISPR Journal
  • doi: 10.1089/crispr.2023.0077
  • PDF

• Sister chromatid cohesion establishment during DNA replication termination.
  • Cameron G, Gruszka DT, Gruar R, Xie S, Kaya Ç, Nasmyth KA, Baxter J, Srinivasan M, Yardimci H
  • Science
  • doi: 10.1126/science.adf0224
  • PDF

• Longitudinal structure-function analysis of molecularly-confirmed CYP4V2 Bietti Crystalline Dystrophy.
  • Cheloni R, Clough N, Jackson D, Moosajee M
  • Eye
  • doi: 10.1038/s41433-023-02791-7
  • PDF

• Under-representation of the WHO African region in clinical trials of interventions against hepatitis B virus infection.
  • Delphin M, Said Mohammed K, Downs LO, Lumley SF, Waddilove E, Okanda D, Aliyan N, Van Schalkwyk M, Anderson M, Ocama P, Maponga T, Torimiro J, Iwuji C, Ndung'u T, Matthews PC, Taljaard J
  • Lancet Gastroenterology and Hepatology
  • doi: 10.1016/S2468-1253(23)00315-1

• Vitamin D regulates microbiome-dependent cancer immunity.
  • Giampazolias E, Pereira da Costa M, Lam KC, Lim KHJ, Cardoso A, Piot C, Chakravarty P, Blasche S, Patel S, Biram A, Castro-Dopico T, Buck MD, Rodrigues RR, Poulsen GJ, Palma-Duran SA, Rogers NC, Koufaki MA, Minutti CM, Wang P, Vdovin A, Frederico B, Childs E, Lee S, Simpson B, Iseppon A, Omenetti S, Kelly G, Goldstone R, Nye E, Suárez-Bonnet A, Priestnall SL, MacRae JI, Zelenay S, Patil KR, Litchfield K, Lee JC, Jess T, Goldszmid RS, Reis e Sousa C
  • Science
  • doi: 10.1126/science.adh7954
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• Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia.
  • Grimm F, Asuaje A, Jain A, Silva Dos Santos M, Kleinjung J, Nunes PM, Gehrig S, Fets L, Darici S, MacRae JI, Anastasiou D
  • The EMBO Journal
  • doi: 10.1038/s44318-024-00065-w
  • PDF

• HIV-1 capsid rapidly induces long-lived CPSF6 puncta in non-dividing cells, but similar puncta already exist in uninfected T-cells
  • Guedán A, Burley M, Caroe ER, Bishop KN
  • Viruses
  • doi: 10.3390/v16050670
  • PDF

• The molecular mechanisms driving Plasmodium cell division
  • Guttery DS, Zeeshan M, Holder AA, Tewari R
  • Biochemical Society Transactions
  • doi: 10.1042/BST20230403
  • PDF

• GNAQ/GNA11 mosaicism is associated with abnormal serum calcium indices and microvascular neurocalcification
  • Knöpfel N, Zecchin D, Richardson H, Polubothu S, Barberan-Martin S, Cullup T, Gholam K, Heales S, Krywawych S, López-Balboa P, Muwanga-Nanyonjo N, Ogunbiyi O, Puvirajasinghe C, Solman L, Swarbrick K, Syed SB, Tahir Z, Tisdall MM, Allgrove J, Chesover AD, Aylett SE, Jacques TS, Hannan FM, Löbel U, Semple RK, Thakker RV, Kinsler VA
  • Journal of Investigative Dermatology
  • doi: 10.1016/j.jid.2023.09.008
  • PDF

• A dynamical perspective: moving towards mechanism in single-cell transcriptomics
  • Maizels RJ
  • Philosophical Transactions of the Royal Society B: Biological Sciences
  • doi: 10.1098/rstb.2023.0049
  • PDF

• ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.
  • Pearson GJ, Mears HV, Broncel M, Snijders AP, Bauer DLV, Carlton JG
  • Science Advances
  • doi: 10.1126/sciadv.adl5012
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• Myeloid C-type lectin receptors in innate immune recognition.
  • Reis e Sousa C, Yamasaki S, Brown GD
  • Immunity
  • doi: 10.1016/j.immuni.2024.03.005
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• CDK activity at the centrosome regulates the cell cycle.
  • Roberts EL, Greenwood J, Kapadia N, Auchynnikava T, Basu S, Nurse P
  • Cell Reports
  • doi: 10.1016/j.celrep.2024.114066
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• Structure-guided design and optimization of covalent VHL-targeted sulfonyl fluoride PROTACs.
  • Shah RR, De Vita E, Sathyamurthi PS, Conole D, Zhang X, Fellows E, Dickinson ER, Fleites CM, Queisser MA, Harling JD, Tate EW
  • Journal of Medicinal Chemistry
  • doi: 10.1021/acs.jmedchem.3c02123
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• Embracing cancer complexity: Hallmarks of systemic disease.
  • Swanton C, Bernard E, Abbosh C, André F, Auwerx J, Balmain A, Bar-Sagi D, Bernards R, Bullman S, DeGregori J, Elliott C, Erez A, Evan G, Febbraio MA, Hidalgo A, Jamal-Hanjani M, Joyce JA, Kaiser M, Lamia K, Locasale JW, Loi S, Malanchi I, Merad M, Musgrave K, Patel KJ, Quezada S, Wargo JA, Weeraratna A, White E, Winkler F, Wood JN, Vousden KH, Hanahan D
  • Cell
  • doi: 10.1016/j.cell.2024.02.009

• GNAQ/GNA11 mosaicism causes aberrant calcium signalling susceptible to targeted therapeutics
  • Zecchin D, Knöpfel N, Gluck AK, Stevenson M, Sauvadet A, Polubothu S, Barberan-Martin S, Michailidis F, Bryant D, Inoue A, Lines KE, Hannan FM, Semple RK, Thakker RV, Kinsler VA
  • Journal of Investigative Dermatology
  • doi: 10.1016/j.jid.2023.08.028
  • PDF

• Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TMBIM4 safeguards IgG1+ GC B cell-positive selection.
  • Zhang L, Toboso-Navasa A, Gunawan A, Camara A, Nakagawa R, Finsterbusch K, Chakravarty P, Newman R, Zhang Y, Eilers M, Wack A, Tolar P, Toellner K-M, Calado DP
  • Science Immunology
  • doi: 10.1126/sciimmunol.adk0092
  • PDF

• Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity.
  • Zhang Y, Morris R, Brown GJ, Lorenzo AMD, Meng X, Kershaw NJ, Kiridena P, Burgio G, Gross S, Cappello JY, Shen Q, Wang H, Turnbull C, Lea-Henry T, Stanley M, Yu Z, Ballard FD, Chuah A, Lee JC, Hatch A-M, Enders A, Masters SL, Headley AP, Trnka P, Mallon D, Fletcher JT, Walters GD, Šestan M, Jelušić M, Cook MC, Athanasopoulos V, Fulcher DA, Babon JJ, Vinuesa CG, Ellyard JI
  • Journal of Experimental Medicine
  • doi: 10.1084/jem.20221080