Preprints February 2024

• Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue

  • Andrews R, Fu B, Toomey CE, Breiter JC, Lachica J, ... Gandhi S, Lee SF
  • doi: 10.1101/2024.02.17.580698

• Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.

  • Koussis K, et al
  • doi: 10.1101/2024.02.04.578801

• Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle size

  • Chu L-Y, et al
  • doi: 10.1101/2024.02.01.578443

• Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

  • Simon CS, McCarthy A, Woods L, Staneva D, Huang Q, et al
  • doi: 10.1101/2024.02.01.578414

• Evolution and inhibition of the FIKK effector kinase family in P. falciparum

  • Belda H, et al
  • doi: 10.1101/2024.02.22.581535

Papers February 2024

• Comparing the immune abnormalities in MIS-C to healthy children and those with inflammatory disease reveals distinct inflammatory cytokine production and a monofunctional T cell response.

  • Butters C, Benede N, Moyo-Gwete T, Richardson SI, Rohlwink U, ... Webb K
  • Clinical Immunology
  • doi: 10.1016/j.clim.2023.109877
  • PDF

• Donor template delivery by recombinant adeno-associated virus for the production of knock-in mice.

  • Duddy G, et al
  • BMC Biology
  • doi: 10.1186/s12915-024-01834-z
  • PDF

• A role for MCH neuron firing in modulating hippocampal plasticity threshold

  • Harris JJ, Burdakov D
  • Peptides
  • doi: 10.1016/j.peptides.2023.171128
  • PDF

• Palisade structure in intact vaccinia virions.

  • Hernandez-Gonzalez M, Calcraft T, Nans A, Rosenthal PB, Way M
  • mBio
  • doi: 10.1128/mbio.03134-23
  • PDF

• Vitamin D status in children with congenital melanocytic nevi.

  • Hughes CT, Dadhra J, Polubothu S, Kinsler VA
  • Pediatric Dermatology
  • doi: 10.1111/pde.15462
  • PDF

• Hepatitis B virus (HBV) screening, linkage and retention-in-care in inclusion health populations: Evaluation of an outreach screening programme in London.

  • Martyn E, et al
  • Journal of Infection
  • doi: 10.1016/j.jinf.2023.12.012

• Integrating cellular electron microscopy with multimodal data to explore biology across space and time.

  • McCafferty CL, Klumpe S, Amaro RE, Kukulski W, Collinson L, Engel BD
  • Cell
  • doi: 10.1016/j.cell.2024.01.005

• Homo sapiens reached the higher latitudes of Europe by 45,000 years ago.

  • Mylopotamitaki D, Weiss M, Fewlass H, et al
  • Nature
  • doi: 10.1038/s41586-023-06923-7
  • PDF

• Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: a systematic review and individual isolate meta-analysis.

  • Nimmo C, et al
  • Lancet Microbe
  • doi: 10.1016/S2666-5247(23)00317-8
  • PDF

• Loss of REP1 impacts choroidal melanogenesis and vasculogenesis in choroideremia.

  • Sarkar H, Tracey-White D, Hagag AM, Burgoyne T, Nair N, ... Moosajee M
  • BBA: Molecular Basis of Disease
  • doi: 10.1016/j.bbadis.2023.166963
  • PDF

• Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing.

  • Soh WT, Roetschke HP, Cormican JA, Teo BF, ... Mishto M
  • Nature Communications
  • doi: 10.1038/s41467-024-45339-3
  • PDF