Paola's MRC-funded project aims to study and clarify the role of neuro-endocrine cells in regulating the function of the thymus, a crucial organ at the intersection of the immune, neuro and endocrine systems.

Recently, Paola's team discovered stem cells in the thymus that give rise to various cell types, including thymic neuro-endocrine cells, characterised by the expression of the ASCL1 transcription factor. By manipulating this gene, the team will gain insights into how it is regulated in neuro-endocrine cells and, more generally, its role in shaping systemic thymic function. 

The expected results will be essential for improving diagnosis and developing targeted therapies for severe autoimmune and neoplastic conditions related to thymic dysfunction.

I am very happy for this important award from the MRC that will allow my group and collaborators to address the role of neuro-endocrine cells in the thymus, both in health and disease.

This builds on the work of Roberta Ragazzini in the lab and the creation of new mouse models in collaboration with the colleagues at the BRF. The project would have not been possible without the help and insights of Francois Guillemot, co-lead in this application. Also, the collaboration with clinicians at the University of Turin and the Great Ormond Street Hospital, has been and will be crucial for the success of the translational aspects of the project.

Paola's lab has been awarded £754,627.

Huge congratulations!