The CrickConnect team are delighted to be able to invite community members to join us for the institute's regular Crick Lecture.

Crick Lectures provide a broad insight into biomedical research from leading scientists. Not to be missed, the one-hour lectures are the event of the week for the Crick community to come together. The lectures aim to be accessible to scientists across different disciplines, while also offering something for the specialist.

This week, Senior Group Leader & Assistant Research Director Sonia Gandhi will be giving the lecture "Thinking big to see small: nanoscopic resolution of protein misfolding in neurodegeneration"

There will also be an opportunity to catch up with colleagues and friends over refreshments after the Lecture from 17:00. If you are able to join us in person at the Crick please let us know at connect@crick.ac.uk so we can arrange access.

Sonia Gandhi

Sonia Gandhi is a Senior Group Leader of the Neurodegeneration Biology Laboratory, and an Assistant Research Director, at The Francis Crick Institute. She is an MRC Senior Clinician Scientist and Professor of Neurology at UCL, where she leads a translational research centre, the UCL Queen Square Movement Disorders Centre, to accelerate translation from scientific discovery to patient benefit, through the discovery of therapeutic targets, biomarkers, and implementing clinical trials.

The Gandhi groups' research programme focusses on understanding the molecular and cellular mechanisms that cause neurodegenerative diseases, specifically familial forms of Parkinson’s disease. Sonia's group has adopted an interdisciplinary approach, combining single molecule biophysics with human stem cell systems to understand how and why proteins misfold in human cells, and then defining the organellar and cellular consequences of protein aggregation. Funded by the global initiative, Aligning Science Across Parkinson’s, her group is utilising a range of single cell, single molecule and spatial technologies to generate a detailed molecular and cellular map the human Parkinson’s brain. Through an MRC Multiscale Program award, her group models subtypes of Parkinson’s across different scales and modalities, integrating cellular, computational, and clinical neuroscience to understand progression in Parkinson’s.