Papers September 2024

• Combining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade.
  • Anastasiou P, Moore C, Rana S, Tomaschko M, Pillsbury CE, de Castro A, Boumelha J, Mugarza E, de Carné Trécesson S, Mikolajczak A, Blaj C, Goldstone R, Smith JAM, Quintana E, Molina-Arcas M, Downward J
  • Nature Communications
  • doi: 10.1038/s41467-024-52324-3
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• Transcription factor-based transdifferentiation of human embryonic to trophoblast stem cells.
  • Balestrini PA, Abdelbaki A, Mccarthy A, Devito L, Senner CE, Chen AE, Munusamy P, Blakeley P, Elder K, Snell P, Christie L, Serhal P, Odia RA, Sangrithi M, Niakan KK, Fogarty NME
  • Development
  • doi: 10.1242/dev.202778
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• Metal-peptidic cages—Helical oligoprolines generate highly anisotropic nanospaces with emergent isomer control
  • Barber BE, Jamieson EMG, White LEM, McTernan CT
  • Chem
  • doi: 10.1016/j.chempr.2024.05.002
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• Hypopituitarism in Sox3 null mutants correlates with altered NG2-glia in the median eminence and is influenced by aspirin and gut microbiota.
  • Galichet C, Rizzoti K, Lovell-Badge R
  • PLoS Genetics
  • doi: 10.1371/journal.pgen.1011395
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• Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma
  • Giangreco G, Rullan A, Naito Y, Biswas D, Liu Y-H, Hooper S, Nenclares P, Bhide S, Chon U Cheang M, Chakravarty P, Hirata E, Swanton C, Melcher A, Harrington K, Sahai E
  • iScience
  • doi: 10.1016/j.isci.2024.110635
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• WIPI2b recruitment to phagophores and ATG16L1 binding are regulated by ULK1 phosphorylation.
  • Gubas A, Attridge E, Jefferies HBJ, Nishimura T, Razi M, Kunzelmann S, Gilad Y, Mercer TJ, Wilson MM, Kimchi A, Tooze SA
  • EMBO Reports
  • doi: 10.1038/s44319-024-00215-5
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• The FAM13A long isoform regulates cilia movement and coordination in airway mucociliary transport.
  • Howes A, Rogerson C, Belyaev N, Karagyozova T, Rapiteanu R, Fradique R, Pellicciotta N, Mayhew D, Hurd C, Crotta S, Singh T, Dingwell K, Myatt A, Arad N, Hasan H, Bijlsma H, Panjwani A, Vijayan V, Young G, Bridges A, Petit-Frere S, Betts J, Larminie C, Smith JC, Hessel EM, Michalovich D, Walport L, Cicuta P, Powell AJ, Beinke S, Wack A
  • American Journal of Respiratory Cell and Molecular Biology
  • doi: 10.1165/rcmb.2024-0063OC
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• mRNA display in cell lysates enables identification of cyclic peptides targeting the BRD3 extraterminal domain.
  • Hurd CA, Bush JT, Powell AJ, Walport LJ
  • Angewandte Chemie International Edition
  • doi: 10.1002/anie.202406414
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• IL-2 delivery to CD8+ T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics.
  • Maurice D, Costello P, Diring J, Gualdrini F, Frederico B, Treisman R
  • Nature Communications
  • doi: 10.1038/s41467-024-52230-8
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• A TNIP1-driven systemic autoimmune disorder with elevated IgG4.
  • Medhavy A, Athanasopoulos V, Bassett K, He Y, Stanley M, Enosi Tuipulotu D, Cappello J, Brown GJ, Gonzalez-Figueroa P, Turnbull C, Shanmuganandam S, Tummala P, Hart G, Lea-Henry T, Wang H, Nambadan S, Shen Q, Roco JA, Burgio G, Wu P, Cho E, Andrews TD, Field MA, Wu X, Ding H, Guo Q, Shen N, Man SM, Jiang SH, Cook MC, Vinuesa CG
  • Nature Immunology
  • doi: 10.1038/s41590-024-01902-0
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• Multistate gene cluster switches determine the adaptive mitochondrial and metabolic landscape of breast cancer.
  • Menegollo M, Bentham RB, Henriques T, Ng SQ, Ren Z, Esculier C, Agarwal S, Tong ETY, Lo C, Ilangovan S, Szabadkai Z, Suman M, Patani N, Ghanate A, Bryson K, Stein RC, Yuneva M, Szabadkai G
  • Cancer Research
  • doi: 10.1158/0008-5472.CAN-23-3172
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• Poised PABP–RNA hubs implement signal-dependent mRNA decay in development
  • Modic M, Kuret K, Steinhauser S, Faraway R, van Genderen E, Ruiz de Los Mozos I, Novljan J, Vičič Ž, Lee FCY, ten Berge D, Luscombe NM, Ule J
  • Nature Structural and Molecular Biology
  • doi: 10.1038/s41594-024-01363-x
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• Morphogens in the evolution of size, shape and patterning.
  • Mosby LS, Bowen AE, Hadjivasiliou Z
  • Development
  • doi: 10.1242/dev.202412
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• CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation.
  • O'Sullivan PA, Aidarova A, Afonina IS, Manils J, Thurston TLM, Instrell R, Howell M, Boeing S, Ranawana S, Herpels M, Chetien R, Bassa M, Flynn H, Frith D, Snijders AP, Howes A, Beyaert R, Bowcock AM, Ley SC
  • Biochemical Journal
  • doi: 10.1042/BCJ20240058
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• Bidirectional activation of stem-like programs between metastatic cancer and alveolar type 2 cells within the niche.
  • Rodrigues FS, Karoutas A, Ruhland S, Rabas N, Rizou T, Di Blasio S, Ferreira RMM, Bridgeman VL, Goldstone R, Sopena ML, Lee J-H, Ombrato L, Malanchi I
  • Developmental Cell
  • doi: 10.1016/j.devcel.2024.05.020
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• The malaria parasite egress protease SUB1 is activated through precise, plasmepsin X-mediated cleavage of the SUB1 prodomain.
  • Withers-Martinez C, George R, Maslen S, Jean L, Hackett F, Skehel M, Blackman MJ
  • Biochimica et Biophysica Acta: General Subjects
  • doi: 10.1016/j.bbagen.2024.130665
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Preprints September 2024

• An integrated stress response-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation
  • Román-Trufero M, Kleijn IT, Blighe K, Zhou J, Saavedra-García P, Gaffar A, Christoforou M, Bellotti A, Abrahams J, Atrih A, Lamont DJ, Gierlinski M, Jayaprakash P, Michel AM, Aboagye E, Yuneva M, Masson GR, Shahrezaei V, Auner HW
  • doi: 10.1101/2024.09.10.611650

• The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
  • Pellowe GA, Voisin TB, Karpauskaite L, Maslen SL, Roeselová A, Skehel JM, Roustan C, George R, Nans A, Kjær S, Taylor IA, Balchin D
  • doi: 10.1101/2024.09.19.613857

• SOX2 drives fetal reprogramming and reversible dormancy in colorectal cancer
  • Baulies A, Moncho-Amor V, Drago-Garcia D, Kucharska A, Chakravarty P, Moreno-Valladares M, Cruces-Salguero S, Hubl F, Hutton C, Kim H, Matheu A, Lovell-Badge R, Li VSW
  • doi: 10.1101/2024.09.11.612412

• Improved resolution of influenza vaccination responses with high-throughput live virus microneutralisation
  • Adams L, Stevenson-Leggett P, Le Lee J, Bazire J, Dowgier G, Hobbs A, Roustan C, Borg A, Carr C, Innocentin S, Webb LMC, Smith C, Bawumia P, Lewis N, O'Reilly N, Kjaer S, Linterman MA, Harvey R, Wu MY, Carr EJ
  • doi: 10.1101/2024.09.13.24313549

• Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multi-site polarity substrate Lgl
  • Earl CP, Cobbaut M, Carvalho AB, Ivanova ME, Briggs DC, Morais-de-Sá E, Parker PJ, McDonald NQ
  • doi: 10.1101/2024.09.26.615224

• SIRPalpha+ PD-L1+ bone marrow macrophages aid AML growth by modulating T cell function
  • Birch F, Gonzalez-Anton S, Haltalli MLR, Chakravarty P, Bruno F, Georgiou C, Mai C, Todd Y, Payne B, Blum S, Pospori C, Arber C, Burt R, Tissot FS, Lo Celso C
  • doi: 10.1101/2024.09.15.613123

• Whole genome sequencing of hepatitis B virus (HBV) using tiled amplicon (HEP-TILE) and probe-based enrichment on Illumina and Nanopore platforms
  • Lumley SF, Kent C, Jennings D, Chai H, Airey G, Waddilove E, Delphin M, Trebes A, McNaughton AL, Said Mohammed K, Wilkinson S, Wu Y, MacIntyre-Cockett G, Kimono B, Kwizera M, Ojambo K, Maponga TG, de Lara C, Martin J, Campbell J, Van Schalkwyk M, Goedhals D, Newton R, Barnes E, Loman NJ, Piazza P, Quick J, Ansari MA, Matthews PC
  • doi: 10.1101/2024.09.11.24313306

• Gonadotrophs have a dual origin, with most derived from pituitary stem cells during minipuberty
  • Sheridan D, Chakravarty P, Golan G, Shiakola Y, Galichet C, Mollard P, Melamed P, Lovell-Badge R, Rizzoti K
  • doi: 10.1101/2024.09.09.610834

• A Drosophila holidic diet optimised for growth and development
  • Sorge S, Girard V, Lampe L, Tixier V, Weaver A, Higgins T, Gould AP
  • doi: 10.1101/2024.09.24.614722

• In vivo CRISPR screens identify GRA12 as a transcendent secreted virulence factor across Toxoplasma gondii strains and mouse subspecies
  • Torelli F, Butterworth S, Lockyer E, Song O-R, Pearson-Farr J, Treeck M
  • doi: 10.1101/2024.09.10.611481

• PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin
  • Fedoryshchak RO, Elbouri K, Joshi D, Mouilleron S, Treisman R
  • doi: 10.1101/2024.09.23.614477