Interviews and commentary June 2024

• Piecing together the mosaic of rare skin diseases: an interview with Veronica Kinsler.
  • Kinsler VA
  • Disease Models and Mechanisms
  • doi: 10.1242/dmm.050636
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• When boundaries benefit science and society.
  • Clark AT, Rossant J, Lovell-Badge R
  • Cell
  • doi: 10.1016/j.cell.2024.05.041

• We can make the UK a science superpower — with a radical political manifesto
  • Nurse P
  • Nature
  • doi: 10.1038/d41586-024-02025-0

Papers June 2024

• Cell adhesion and migration in disease: translational and therapeutic opportunities
  • Anderson K, Calle-Patino Y, Ivetic A, Parsons M, Valderrama F, Wells C, Anton I
  • Cell Adhesion and Migration
  • doi: 10.1080/19336918.2024.2362978
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• Strategies for selecting and managing equipment in a light microscopy facility.
  • Anderson KI
  • Journal of Microscopy
  • doi: 10.1111/jmi.13316
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• The sex of organ geometry.
  • Blackie L, Gaspar P, Mosleh S, Lushchak O, Kong L, Jin Y, Zielinska AP, Cao B, Mineo A, Silva B, Ameku T, Lim SE, Mao Y, Prieto-Godino L, Schoborg T, Varela M, Mahadevan L, Miguel-Aliaga I
  • Nature
  • doi: 10.1038/s41586-024-07463-4
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• Polyextremophile engineering: a review of organisms that push the limits of life
  • Caro-Astorga J, Meyerowitz JT, Stork DA, Nattermann U, Piszkiewicz S, Vimercati L, Schwendner P, Hocher A, Cockell C, DeBenedictis E
  • Frontiers in Microbiology
  • doi: 10.3389/fmicb.2024.1341701
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• Rapid peptide cyclization inspired by the modular logic of nonribosomal peptide synthetases.
  • Ding Y, Lambden E, Peate J, Picken LJ, Rees TW, Perez-Ortiz G, Newgas SA, Spicer LAR, Hicks T, Hess J, Ulmschneider MB, Müller MM, Barry SM
  • Journal of the American Chemical Society
  • doi: 10.1021/jacs.4c04711
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• Disruption of common ocular developmental pathways in patient-derived optic vesicle models of microphthalmia.
  • Eintracht J, Owen N, Harding P, Moosajee M
  • Stem Cell Reports
  • doi: 10.1016/j.stemcr.2024.05.001
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• Spatial architecture of myeloid and T cells orchestrates immune evasion and clinical outcome in lung cancer.
  • Enfield KSS, Colliver E, Lee C, Magness A, Moore DA, Sivakumar M, Grigoriadis K, Pich O, Karasaki T, Hobson PS, Levi D, Veeriah S, Puttick C, Nye EL, Green M, Dijkstra KK, Shimato M, Akarca AU, Marafioti T, Salgado R, Hackshaw A, TRACERx Consortium, Jamal-Hanjani M, van Maldegem F, McGranahan N, Glass B, Pulaski H, Walk E, Reading JL, Quezada SA, Hiley CT, Downward J, Sahai E, Swanton C, Angelova M
  • Cancer Discovery
  • doi: 10.1158/2159-8290.CD-23-1380
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• CD1 molecules: Beyond antigen presentation.
  • Evans L, Barral P
  • Molecular Immunology
  • doi: 10.1016/j.molimm.2024.03.011
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• Germinal center versus extrafollicular responses in systemic autoimmunity: Who turns the blade on self?
  • He Y, Vinuesa CG
  • Advances in Immunology
  • doi: 10.1016/bs.ai.2024.02.002
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• N-terminal cysteine acetylation and oxidation patterns may define protein stability.
  • Heathcote KC, Keeley TP, Myllykoski M, Lundekvam M, McTiernan N, Akter S, Masson N, Ratcliffe PJ, Arnesen T, Flashman E
  • Nature Communications
  • doi: 10.1038/s41467-024-49489-2
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• Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling
  • Hobor S, Al Bakir M, Hiley CT, Skrzypski M, Frankell AM, Bakker B, Watkins TBK, Markovets A, Dry JR, Brown AP, van der Aart J, van den Bos H, Spierings D, Oukrif D, Novelli M, Chakrabarti T, Rabinowitz AH, Ait Hassou L, Litière S, Kerr DL, Tan L, Kelly G, Moore DA, Renshaw MJ, Venkatesan S, Hill W, Huebner A, Martínez-Ruiz C, Black JRM, Wu W, Angelova M, McGranahan N, Downward J, Chmielecki J, Barrett C, Litchfield K, Chew SK, Blakely CM, de Bruin EC, Foijer F, Vousden KH, Bivona TG, TRACERx consortium, Hynds RE, Kanu N, Zaccaria S, Grönroos E, Swanton C
  • Nature Communications
  • doi: 10.1038/s41467-024-47606-9
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• Divergent evolution of sleep in Drosophila species.
  • Joyce M, Falconio FA, Blackhurst L, Prieto-Godino L, French AS, Gilestro GF
  • Nature Communications
  • doi: 10.1038/s41467-024-49501-9
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• m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation.
  • Klein P, Petrić Howe M, Harley J, Crook H, Esteban Serna S, Roumeliotis TI, Choudhary JS, Chakrabarti AM, Luisier R, Patani R, Ramos A
  • Nature Communications
  • doi: 10.1038/s41467-024-49139-7
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• Oncogenic cell tagging and single-cell transcriptomics reveal cell type-specific and time-resolved responses to Vhl inactivation in the kidney.
  • Kurlekar S, Lima JDCC, Li R, Lombardi O, Masson N, Barros AB, Pontecorvi V, Mole DR, Pugh CW, Adam J, Ratcliffe PJ
  • Cancer Research
  • doi: 10.1158/0008-5472.CAN-23-3248
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• Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX.
  • Magness A, Colliver E, Enfield KSS, Lee C, Shimato M, Daly E, Moore DA, Sivakumar M, Valand K, Levi D, Hiley CT, Hobson PS, van Maldegem F, Reading JL, Quezada SA, Downward J, Sahai E, Swanton C, Angelova M
  • Nature Communications
  • doi: 10.1038/s41467-024-48870-5
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• Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics.
  • Mallach A, Zielonka M, van Lieshout V, An Y, Khoo JH, Vanheusden M, Chen W-T, Moechars D, Arancibia-Carcamo IL, Fiers M, De Strooper B
  • Cell Reports
  • doi: 10.1016/j.celrep.2024.114216
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• Covalent fragment-based drug discovery for target tractability.
  • McCarthy WJ, van der Zouwen AJ, Bush JT, Rittinger K
  • Current Opinion in Structural Biology
  • doi: 10.1016/j.sbi.2024.102809
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• Natural proteome diversity links aneuploidy tolerance to protein turnover.
  • Muenzner J, Trébulle P, Agostini F, Zauber H, Messner CB, Steger M, Kilian C, Lau K, Barthel N, Lehmann A, Textoris-Taube K, Caudal E, Egger A-S, Amari F, De Chiara M, Demichev V, Gossmann TI, Mülleder M, Liti G, Schacherer J, Selbach M, Berman J, Ralser M
  • Nature
  • doi: 10.1038/s41586-024-07442-9
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• Community dialogue to enhance understanding of beliefs, behaviours and barriers to care for people living with liver disease and HBV infection in KwaZulu Natal, South Africa
  • Ngwenya B, Anderson M, Mpanza N, Mbokazi W, Zuma L, Khoza T, Sukali G, Waddilove E, Delphin M, Iwuji C, Mhlongo N, Majozi N, Seeley J, Upton J, Harling G, Matthews PC, Edwards A
  • Journal of Virus Eradication
  • doi: 10.1016/j.jve.2024.100378
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• Oncogenic extrachromosomal DNA identification using whole-genome sequencing from formalin-fixed glioblastomas
  • Noorani I, Luebeck J, Rowan A, Grönroos E, Barbe V, Fabian M, Nicoll JAR, Boche D, Bafna V, Mischel PS, Swanton C
  • Annals of Oncology
  • doi: 10.1016/j.annonc.2024.03.008
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• Inflammatory linear verrucous epidermal nevus should be genotyped to direct treatment and genetic counseling
  • Polubothu S, Riachi M, Stadnik P, Ogunbiyi O, Brändli-Wälchli R, Cullup T, Sebire NJ, Pittman A, Kinsler VA
  • Journal of the American Academy of Dermatology
  • doi: 10.1016/j.jaad.2024.01.075
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• Tales from the crick: The art of demo.
  • Renshaw MJ, Charoy C
  • Journal of Microscopy
  • doi: 10.1111/jmi.13305
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• A disease-associated gene desert directs macrophage inflammation through ETS2.
  • Stankey CT, Bourges C, Haag LM, Turner-Stokes T, Piedade AP, Palmer-Jones C, Papa I, Silva Dos Santos M, Zhang Q, Cameron AJ, Legrini A, Zhang T, Wood CS, New FN, Randzavola LO, Speidel L, Brown AC, Hall A, Saffioti F, Parkes EC, Edwards W, Direskeneli H, Grayson PC, Jiang L, Merkel PA, Saruhan-Direskeneli G, Sawalha AH, Tombetti E, Quaglia A, Thorburn D, Knight JC, Rochford AP, Murray CD, Divakar P, Green M, Nye E, MacRae JI, Jamieson NB, Skoglund P, Cader MZ, Wallace C, Thomas DC, Lee JC
  • Nature
  • doi: 10.1038/s41586-024-07501-1
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• Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING.
  • Takaki T, Millar R, Hiley CT, Boulton SJ
  • Molecular Cell
  • doi: 10.1016/j.molcel.2024.04.017
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Preprints June 2024

• Illuminating morphogen and patterning dynamics with optogenetic control of morphogen production
  • Benzinger D, Briscoe J
  • doi: 10.1101/2024.06.11.598403

• IP10 levels refine severity prognostication in COVID-19 and implicate causes of clinical deterioration: lessons for pandemic preparedness
  • Das A, Wei J, McKenzie D, Snell L, Sasidharan S, Vantourout P, Zlatareva I, Merrick B, Thomas B, Adiga V, Hussain K, Batra R, Davies D, Su J, Bisnauthsing K, Martinez L, Ahmed A, Bindhu H, Chetan N, Macrina M, Tripathi H, O'Hara G, Fairhead C, Drazdauskaite G, Lock H, Dias M, Ibrahim MAA, Hayday T, D'Souza G, Edgeworth JD, Vyakarnam A, Pouwels KB, Hayday AC
  • doi: 10.1101/2024.06.15.24308935

• Growth-induced physiological hypoxia correlates with growth deceleration during normal development
  • Zhao Y, Alexandre C, Kelly G, Perez-Mockus G, Vincent J-P
  • doi: 10.1101/2024.06.04.597345

• Structural insight into the function of human peptidyl arginine deiminase 6
  • Williams JPC, Mouilleron S, Hernandez Trapero R, Bertran MT, Marsh JA, Walport LJ
  • doi: 10.1101/2024.06.10.598250